Insights into cancer biology from the study of basepair-level changes in coding sequences. Genotyping vs. resequencing. Identifying cancer-related... » More

Insights into cancer biology from the study of basepair-level changes in coding sequences. Genotyping vs. resequencing. Identifying cancer-related genes using association studies. Use of next-generation sequencing technologies to map chromosomal aberrations in cancer genomes. PCR-based resequencing vs. array-based enrichment. Using recurrence, pathway enrichment, and other signatures of positive selection to identify "driver" somatic mutations involved in cancer progression. Part of the Computer-Aided Discovery Methods course taught at Baylor College of Medicine

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