biosights: February 16, 2015 - Filopodia point the way for haptotaxis

submitted by: JCB
Migrating fibroblasts maintain or change their direction by branching off new lamellipodia from existing protrusions at the cell's leading edge. Johnson et al. reveal that filopodial protrusions initiate and orient these lamellipodia, helping fibroblasts navigate gradients of immobilized guidance cues. This biosights episode presents the paper by Johnson et al. from the February 16, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Jason...

biosights: January 19, 2015 - Tubulin transport pumps up cilia

submitted by: JCB
The assembly of cilia and flagella requires the delivery of large amounts of tubulin to the growing ends of the organelles' microtubules. Craft et al. reveal that tubulin loading onto intraflagellar transport particles is specifically upregulated in growing cilia. This biosights episode presents the paper by Craft et al. from the January 19, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Karl Lechtreck (University of Georgia, Athens, GA)....

biosights: December 22, 2014 - Osmotic gradient is just the tonic for wounded epithelia

submitted by: JCB
Rapid wound repair is generally thought to be initiated by intrinsic cues, such as changes in the structure or mechanics of damaged tissues. Gault et al. reveal that an extrinsic signal — the osmolarity of the external environment — can stimulate wound closure in zebrafish by inducing epithelial cell migration. This biosights episode presents the paper by Gault et al. from the December 22, 2014, issue of The Journal of Cell Biology and includes an interview with the paper's senior...

biosights: November 24, 2014 - Dynein helps centrioles stick together

submitted by: JCB
Dynein has numerous functions in mitosis, but the function of the motor complex's light intermediate chains is poorly understood. Jones et al. reveal that dynein's light intermediate chains are required to maintain centrosome integrity during mitosis, preventing the premature separation of mother-daughter centrioles and the formation of multipolar spindles. This biosights episode presents the paper by Jones et al. from the November 24, 2014, issue of The Journal of Cell Biology and includes...

Faster, more sensitive imaging of live cells – Biotech’s future

submitted by: nsf

Developing new drugs means researchers must observe how cells react to those drugs over extended periods of time. NSF-funded small business Phi Optics has developed an optical microscope that lets scientists do just that -- study living cells in their natural environments. Catalin Chiritescu talked about how the technology works at the 2014 BIO International Convention.

biosights: October 27, 2014 - Epithelial cells make changes at the top

submitted by: JCB
The apical surfaces of polarized epithelia are covered by short, actin-rich protrusions called microvilli, but what happens to these structures when cells detach from a monolayer during development or disease is unclear. Klingner et al. reveal that non-confluent epithelial cells form longer, more dynamic microvilli on their apical surface that connect to a cortical actomyosin network. This biosights episode presents the paper by Klingner et al. from the October 13, 2014, issue of The Journal...