Making Muscle: Tissue Engineering in MUSC's Department of Surgery

submitted by: mcgheek
Samir Fakhry, M.D., Chief of MUSC's Division of General Surgery, and Michael Yost, PhD, Associate Chair of Research in MUSC's Department of Surgery, discuss the promise of engineered tissues for the treatment of surgical and trauma patients. Engineered tissue can instruct the body to regenerate native tissue instead of generating scar, improving cosmetic and functional outcomes. Bioprinters, 3D printers for living tissue, will help realize the promise of engineered tissue for clinical care.k

biosights: April 14, 2014 - An actin lever flattens out the cell

submitted by: JCB
The lamella is a broad, flat region that forms at the front of migrating cells and adheres to the underlying substrate. Burnette et al. reveal that cells flatten out the lamella by mechanically coupling a contractile actomyosin network at the dorsal surface to ventral cell adhesions. This biosights episode presents the paper by Burnette et al. from the April 14, 2014, issue of The Journal of Cell Biology and includes an interview with authors Dylan Burnette (Vanderbilt University School of...

Rotating Egg

submitted by: hsrikm

Graph of an egg derived from an equation and uneven unique angular periods from division of pi by whole numbers.

biosights: March 17, 2014 - Blebs lead the way in Dictyostelium chemotaxis

submitted by: JCB
Membrane blebs can help the leading edge of migrating cells protrude forwards, but the contribution of blebs to the motility of Dictyostelium cells is unclear. Zatulovskiy et al. reveal that blebs form at the front of chemotaxing Dictyostelium cells, particularly when the cells are faced with a mechanically resistant environment, and that this process is guided by a PI3-kinase-dependent signaling pathway. This biosights episode presents the paper by Zatulovskiy et al. from the March 17,...

biosights: February 17, 2014 - Shroom takes embryos to new dimensions

submitted by: JCB
During development, the planar polarized distribution of Rho kinase and Myosin II helps Drosophila germ-band cells intercalate so that the embryo extends along its anterior-posterior axis. Simoes et al. reveal how Rho GTPase and the actin-binding protein Shroom combine to regulate the localization of Rho kinase and actomyosin contractility during axis elongation. This biosights episode presents the paper by Simoes et al. from the February 17, 2014, issue of The Journal of Cell Biology and...

Novel cell-based and materials science approach to target Glioblastoma brain cancer tumors

submitted by: nsf

Stefan Bossmann and Deryl Troyer at Kansas State University are developing a novel materials treatment method for persons with brain cancer that uses a type of white blood cell to deliver anticancer drugs to particularly virulent brain tumors.