Intestinal roundworms infect >2 billion of the poorest peoples and have received little attention. Very little money is spent on much needed drug development for human parasites, making them one of the great neglected tropical diseases. Recently, a new and powerful class of anti-roundworm drugs (anthelmintic) has emerged- crystal proteins (e.g., Cry5B) made by Bacillus thuringiensis (Bt). Here we show that combining Cry5B with nicotinic acetylcholine receptor agonists like tribendimidine and...