Microbial signature profiles of periodontally healthy and diseased patients

submitted by: apcolombo
Aim: To determine microbial profiles that discriminate periodontal health from different forms of periodontal diseases. Methods: Subgingival biofilm was obtained from patients with periodontal health (27), gingivitis (11), chronic periodontitis (35) and aggressive periodontitis (24), and analysed for the presence of >250 species/phylotypes using HOMIM. Microbial differences among groups were examined by Mann–Whitney U-test. Regression analyses were performed to determine microbial...
Authors: Talita Lourenço, Debora Heller, Carina Silva-Boghossian, Sean Cotton, Bruce Paster, Ana Paula Colombo

Breakthrough Therapies for Idiopathic Pulmonary Fibrosis

submitted by: mcgheek

Timothy P.M. Whelan, M.D., Medical Director of the Lung Transplant Program at the Medical University of South Carolina, discusses promising clinical trial results of new agents (pirfenidone, nintedanib) for the treatment of idiopathic pulmonary fibrosis (IPF). To date, only supportive care and transplant (for eligible patients) have been available to IPF patients, but these new trial results could lead to FDA approval of the first drugs for IPF.

MyD88 knockout mice develop initial enlarged periapical

AIM: To characterize the formation and progression of experimentally induced periapical lesions in teeth of MyD88 knockout (MyD88 KO) mice compared with wild-type (WT) mice. METHODOLOGY: Periapical lesions were induced in the mandibular first molars of 30 WT and 30 MyD88 KO mice. After 7, 21 and 42 days, the animals were euthanized and the mandibles were subjected to histotechnical processing. Histological sections were stained with haematoxylin and eosin (HE), TRAP histoenzymology,...
Authors: Raquel Assed Bezerra da Silva, Paulo Nelson-Filho, Marília Pacífico Lucisano, Andiara De Rossi, Alexandra Mussolino de Queiroz, Lea Assed Bezerra da Silva

Helping health care technologies communicate

submitted by: nsf
Julian Goldman, a physician at Mass General Hospital, knows better than most the frustrations that doctors face when they're confronted with computer systems and devices that just won't communicate with each other. His lab has been a pioneer in developing open source tools and standards designed to integrate the various technologies used in homes and hospitals. The effort, in turn, led to the development of a community of likeminded researchers and manufacturers that would like to break...

Health care that follows you from home to hospital and back

submitted by: nsf
Professor Marjorie Skubic from the University of Missouri has created a suite of health care technologies that identify when an individual falls in their home or when their physical behavior changes over time. However, how does a physician at a hospital know about and use information gathered by devices like those designed by Skubic for the home? And likewise, how does information about a patient's condition in the hospital get incorporated into technologies like Skubic's when they return...

Deformation and fracture incidence of Reciproc instruments: a clinical evaluation.

submitted by: gplotino
Aim To investigate the incidence of fracture and deformation observed on Reciproc instruments after clinical use. Methodology A total of 1696 Reciproc NiTi instruments that were discarded after normal clinical usage over 30 months were collected, 1580 instruments were R25 (93%), 76 were R40 (5%) and 40 were R50 (2%). The treatments included 3780 root canal preparation, 3023 primary treatments and 757 retreatments. Root canal preparation was standardized and followed the manufacturer's...
Authors: Gianluca Plotino, Nicola Maria Grande, Pier Francesco Porciani