biosights: November 24, 2014 - Dynein helps centrioles stick together

submitted by: JCB
Dynein has numerous functions in mitosis, but the function of the motor complex's light intermediate chains is poorly understood. Jones et al. reveal that dynein's light intermediate chains are required to maintain centrosome integrity during mitosis, preventing the premature separation of mother-daughter centrioles and the formation of multipolar spindles. This biosights episode presents the paper by Jones et al. from the November 24, 2014, issue of The Journal of Cell Biology and includes...

The Importance of Technology in the 'Omics Lab

submitted by: Chrom Solutions

Dr. Matthias Mann, Director of the Max Planck Institute of Biochemistry, talks about how impactful innovative technology, like the Orbitrap, has been in his lab. The end goal of his collaboration with Thermo Fisher Scientific is to build a system that anyone can use to "dramatically extend the reach and impact of proteomics.

biosights: October 27, 2014 - Epithelial cells make changes at the top

submitted by: JCB
The apical surfaces of polarized epithelia are covered by short, actin-rich protrusions called microvilli, but what happens to these structures when cells detach from a monolayer during development or disease is unclear. Klingner et al. reveal that non-confluent epithelial cells form longer, more dynamic microvilli on their apical surface that connect to a cortical actomyosin network. This biosights episode presents the paper by Klingner et al. from the October 13, 2014, issue of The Journal...

Translation Workflow Development using Mass Spectrometry

submitted by: Chrom Solutions
Mary Lopez, Ph.D. discusses translational workflows developed by the BRIMS center, designed to address all aspects of proteomics, from biomarker discovery to developing more routine applications using mass spectrometry. The workflows can be divided into two different types-- discovery and targeted. High-resolution mass spectrometry instruments are used during the discovery phase to analyze complex biological samples in an effort to uncover new biomarkers by looking at differential abundance....

San Jose Facility Now Registered as Medical Device Establishment

submitted by: Chrom Solutions

Thermo Fisher Scientific's San Jose, California facility registered with the U.S. Food and Drug Administration (FDA) as a medical device establishment. The site has established a quality system in accordance with the FDA Quality System Regulations to design and manufacture devices for analyzing samples from patients for in vitro diagnostic use.

Vanquish UHPLC System: Detect the Analyte

submitted by: Chrom Solutions

~1 minute animation video for the new Vanquish UHPLC system describing the new diode array detector, with animations for how the sample is detected on the detector.