Vanquish UHPLC System: Introduce the Sample

submitted by: Chrom Solutions

~1 minute animation video for the new Vanquish UHPLC system describing the new autosampler and charger module, with animations for how the sample moves through the autosampler and the high throughput capabilities of the system.

Vanquish UHPLC System: Drive the Separation

submitted by: Chrom Solutions

~1 minute animation video for the new Vanquish UHPLC system describing the new pump, with animations for driving the separation through the workflow.

biosights: September 29, 2014 - Cdc42 prompts a change of heart

submitted by: JCB
The Drosophila heart is a simple tubular structure with a central lumen. Vogler et al. reveal that the small GTPase Cdc42 and actin-nucleating formin proteins promote lumen formation by regulating the dynamics of non-muscle myosin in cardioblasts during heart morphogenesis. This biosights episode presents the paper by Vogler et al. from the September 29, 2014, issue of The Journal of Cell Biology and includes an interview with two of the paper's authors, Georg Vogler and Rolf Bodmer...

Systematic detection of internal symmetry in proteins

submitted by: Spencer Bliven

Talk presented at the 28th Rhine-Knee Regional Meeting on Biocrystallography on Sept 25, 2014.

biosights: September 1, 2014 - Deploying exosomes in a battle of the sexes

submitted by: JCB
The paired accessory glands of male Drosophila secrete multiple signaling factors into the seminal fluid that promote reproductive success by altering the recipient female's physiology and behavior. Corrigan et al. reveal that the secondary cells of accessory glands secrete membrane-bound exosomes in a BMP-dependent manner that, after being transferred into the female reproductive tract, inhibit the female's inclination to re-mate with other male flies. This biosights episode presents the...

biosights: August 4, 2014 - Rok keeps its finger on the pulse of apical constriction

submitted by: JCB
Early in Drosophila embryogenesis, contractile pulses of myosin assembly and disassembly constrict the apical domains of a group of epithelial cells to drive their invagination into a ventral furrow. Vasquez et al. reveal that Rho kinase and myosin phosphatase dynamically regulate these myosin pulses and that the stepwise constriction resulting from this helps maintain tissue integrity during epithelial invagination. This biosights episode presents the paper by Vasquez et al. from the August...