biosights: September 29, 2014 - Cdc42 prompts a change of heart

submitted by: JCB
The Drosophila heart is a simple tubular structure with a central lumen. Vogler et al. reveal that the small GTPase Cdc42 and actin-nucleating formin proteins promote lumen formation by regulating the dynamics of non-muscle myosin in cardioblasts during heart morphogenesis. This biosights episode presents the paper by Vogler et al. from the September 29, 2014, issue of The Journal of Cell Biology and includes an interview with two of the paper's authors, Georg Vogler and Rolf Bodmer...

Systematic detection of internal symmetry in proteins

submitted by: Spencer Bliven

Talk presented at the 28th Rhine-Knee Regional Meeting on Biocrystallography on Sept 25, 2014.

biosights: September 1, 2014 - Deploying exosomes in a battle of the sexes

submitted by: JCB
The paired accessory glands of male Drosophila secrete multiple signaling factors into the seminal fluid that promote reproductive success by altering the recipient female's physiology and behavior. Corrigan et al. reveal that the secondary cells of accessory glands secrete membrane-bound exosomes in a BMP-dependent manner that, after being transferred into the female reproductive tract, inhibit the female's inclination to re-mate with other male flies. This biosights episode presents the...

biosights: August 4, 2014 - Rok keeps its finger on the pulse of apical constriction

submitted by: JCB
Early in Drosophila embryogenesis, contractile pulses of myosin assembly and disassembly constrict the apical domains of a group of epithelial cells to drive their invagination into a ventral furrow. Vasquez et al. reveal that Rho kinase and myosin phosphatase dynamically regulate these myosin pulses and that the stepwise constriction resulting from this helps maintain tissue integrity during epithelial invagination. This biosights episode presents the paper by Vasquez et al. from the August...

HERESY AND MEDICINE IN THE MIDDLE AGES

submitted by: camdic

"I fought a lot; I thought I could win, but fate and nature repressed my study and my efforts. But it is already something to be on the battlefield, because to win depends very much on fortune. But I did as much as I could, and I do not think anyone, of the future generation, will deny it. I was not afraid of death, I never gave in to anyone, I chose courageous death instead of a coward’s life". Giordano Bruno, De Monade (1591).

Annalee Newitz at the 2014 DOE JGI Genomics of Energy & Environment Meeting

submitted by: JGI

Annalee Newitz, io9, at the 9th Annual Genomics of Energy & Environment Meeting on March 20, 2014 in Walnut Creek, Calif.