Cultures Magazine Launch Event - MWV84

submitted by: MicrobeWorld

Watch highlights from the Cultures Magazine Launch Event held on January 23, 2014 at American Society for Microbiology headquarters in Washington, D.C.

Cultures is a free, online, open-source publication available for viewing at www.asm.org/cultures.

biosights: February 17, 2014 - Shroom takes embryos to new dimensions

submitted by: JCB
During development, the planar polarized distribution of Rho kinase and Myosin II helps Drosophila germ-band cells intercalate so that the embryo extends along its anterior-posterior axis. Simoes et al. reveal how Rho GTPase and the actin-binding protein Shroom combine to regulate the localization of Rho kinase and actomyosin contractility during axis elongation. This biosights episode presents the paper by Simoes et al. from the February 17, 2014, issue of The Journal of Cell Biology and...

Melanin-concentrating hormone receptor 1 polymorphisms are associated with components of energy balance in the CODING study

submitted by: bfontain
BACKGROUND: The melanin-concentrating hormone receptor 1 (MCHR1) is a G protein-coupled receptor that regulates energy balance and body composition in animal models. Inconsistent effects of MCHR1 polymorphisms on energy homeostasis in humans may partly be attributable to environmental factors. OBJECTIVES: We examined the effect of 4 single nucleotide polymorphisms (rs133073, rs133074, rs9611386, and rs882111) in the MCHR1 gene on body composition as well as energy-related lifestyle...
Authors: Bénédicte Fontaine-Bisson, James Thorburn, Anne Gregory, Hongwei Zhang, Guang Sun

biosights: January 20, 2014 - Motors give a new twist to platelet activation

submitted by: JCB
The discoid shape of resting platelets is maintained by a peripheral ring of bundled microtubules called the marginal band. Diagouraga et al. reveal that, upon platelet activation, the motor protein dynein slides microtubules apart, inducing marginal band coiling and the conversion of platelets to a spherical shape. This biosights episode presents the paper by Diagouraga et al. from the January 20, 2014, issue of The Journal of Cell Biology and includes an interview with senior author Karin...

Science Behind the News: Influenza & Flu Vaccines

submitted by: nsf

Every flu season, Americans battle coughs, fevers and body aches. The flu is a respiratory illness caused by a virus, a pathogen that causes disease in the human body. To understand how the flu is caught, spread and treated, Duke University's Katia Koelle explains the biology of a virus and how it is transmitted. "Science Behind the News" is produced in partnership with NBC Learn.

Provided by the National Science Foundation & NBC Learn

Silencing the Menkes Copper-Transporting ATPase (Atp7a) Gene in Rat Intestinal Epithelial (IEC-6) Cells Increases Iron Flux via Transcriptional Induction of Ferroportin 1 (Fpn1)

submitted by: jfcollins
The Menkes copper-transporting ATPase (Atp7a) gene is induced in rat duodenum during iron deficiency, consistent with copper accumulation in the intestinal mucosa and liver. To test the hypothesis that ATP7A influences intestinal iron metabolism, the Atp7a gene was silenced in rat intestinal epithelial (IEC-6) cells using short hairpin RNA (shRNA) technology. Perturbations in intracellular copper homeostasis were noted in knockdown cells, consistent with the dual roles of ATP7A in pumping...
Authors: Sukru Gulec, James F. Collins