Navy veteran studies genetic variation - Scientists & Engineers on Sofas (and other furnishings)

submitted by: nsf

Graduate Research Fellow Amy Battocletti is a Navy veteran who was awarded a Graduate Research Fellowship in 2014. She’s a doctoral candidate in biology at Georgetown University conducting research on the impact of genetic variation within plant species in salt marsh ecosystems.

Credit: National Science Foundation

biosights: May 11, 2015 - Formin' actin at adherens junctions

submitted by: JCB
Actin assembly promotes the formation of intercellular adherens junctions, but the role of actin-nucleating formin proteins in this process remains unclear. Grikscheit et al. reveal that, in breast epithelial cells cultured in 3D, the formin FMNL2 stimulates junctional actin assembly downstream of the small GTPase Rac1. This biosights episode presents the paper by Grikscheit et al. from the May 11, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior...

3D Cell Movie

submitted by: MCW_BBC

Images of cells from Confocal Microscope System combined with fluorescence correlation spectroscopy

biosights: April 13, 2015 - A motif that helps myosin II-B lead from behind

submitted by: JCB
Myosin II-A and myosin II-B play distinct roles in establishing the front–back polarity of migrating mesenchymal cells. Juanes-Garcia et al. identify a short, serine-rich motif in the non-helical tail domain of myosin II-B that enables this isoform to form stable actomyosin bundles that define the cell rear. This biosights episode presents the paper by Juanes-Garcia et al. from the April 13, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior...

Mar 20, 2015; iDASH External Webinar; Amalio Telenti

submitted by: ucsd_idash
Privacy issues when looking for a needle in a genomic haystack Amalio Telenti Human Longevity Inc. Abstract: Very rare single nucleotide variants are the most prevalent form of genetic diversity in the human population. Such variants are generally refered to as Variants of Unknown Significance (VUS). It is expected that VUS will attract increasing attention of the medical services as possibly associated with clinical disease or disease predisposition. The considerations above call...

biosights: March 16, 2015 - PAPC separates tissues at a Snail's pace

submitted by: JCB
Brachet's cleft separates the ectoderm and mesoderm of early Xenopus and zebrafish embryos. Luu et al. reveal that, in conjunction with the transcription factor Snail1, the protocadherin PAPC promotes tissue separation by down-regulating planar cell polarity proteins at the ectoderm-mesoderm boundary. This biosights episode presents the paper by Luu et al. from the March 16, 2015, issue of The Journal of Cell Biology and includes an interview with one of the paper's senior authors, Rudolf...