Making Muscle: Tissue Engineering in MUSC's Department of Surgery

submitted by: mcgheek
Samir Fakhry, M.D., Chief of MUSC's Division of General Surgery, and Michael Yost, PhD, Associate Chair of Research in MUSC's Department of Surgery, discuss the promise of engineered tissues for the treatment of surgical and trauma patients. Engineered tissue can instruct the body to regenerate native tissue instead of generating scar, improving cosmetic and functional outcomes. Bioprinters, 3D printers for living tissue, will help realize the promise of engineered tissue for clinical care.k

Congenital Heart Defects: Could the Developing Heart Hold the Key to New Therapies?

submitted by: mcgheek

Andrew M. Atz, M.D., Chief of the Division of Pediatric Cardiology at MUSC's Children's Hospital, and Kyu-Ho Lee, M.D., PhD, a developmental biologist at MUSC's Cardiovascular Developmental Biology Center, discuss how better understanding the gene signaling involved in the embryonic development of the heart could lead to new adjunctive therapies for congenital heart defects. Learn more about Dr. Lee's work in the November 2013 issue of Progressnotes at MUSChealth.com/progressnotes

3/3/14 Special External Webinar: Cardiac Atlas Project

submitted by: ucsd_idash
Cardiac Atlas Project Alistair Young School of Medicine, University of Auckland Andrew McCulloch University of California San Diego Abstract: Cardiac malformations are the most common type of birth defect. Improvements in the management of complex congenital heart disease (CHD) have resulted in >90% of those born with CHD now able to survive into early adulthood. In the U.S. alone, there are more adults with CHD (~1 million individuals) than children. Many of these patients...

Cultures Magazine Launch Event - MWV84

submitted by: MicrobeWorld

Watch highlights from the Cultures Magazine Launch Event held on January 23, 2014 at American Society for Microbiology headquarters in Washington, D.C.

Cultures is a free, online, open-source publication available for viewing at www.asm.org/cultures.

Novel cell-based and materials science approach to target Glioblastoma brain cancer tumors

submitted by: nsf

Stefan Bossmann and Deryl Troyer at Kansas State University are developing a novel materials treatment method for persons with brain cancer that uses a type of white blood cell to deliver anticancer drugs to particularly virulent brain tumors.

Silencing the Menkes Copper-Transporting ATPase (Atp7a) Gene in Rat Intestinal Epithelial (IEC-6) Cells Increases Iron Flux via Transcriptional Induction of Ferroportin 1 (Fpn1)

submitted by: jfcollins
The Menkes copper-transporting ATPase (Atp7a) gene is induced in rat duodenum during iron deficiency, consistent with copper accumulation in the intestinal mucosa and liver. To test the hypothesis that ATP7A influences intestinal iron metabolism, the Atp7a gene was silenced in rat intestinal epithelial (IEC-6) cells using short hairpin RNA (shRNA) technology. Perturbations in intracellular copper homeostasis were noted in knockdown cells, consistent with the dual roles of ATP7A in pumping...
Authors: Sukru Gulec, James F. Collins