Organs on a chip

submitted by: nsf

Organs on a chip systems could transform the medical drug pipeline as we know it. Biomedical engineer Ali Khademhosseini explains how he and his team at MIT are engineering tissues outside of the human body and connecting different "organs" to solve some pressing challenges.

Engineering a Smart Bandaid

submitted by: nsf

What does it take to engineer a smart bandaid? Biomedical engineer Ali Khademhosseini walks us through the future of bandaids, and how he and his team at MIT are testing them.

biosights: November 24, 2014 - Dynein helps centrioles stick together

submitted by: JCB
Dynein has numerous functions in mitosis, but the function of the motor complex's light intermediate chains is poorly understood. Jones et al. reveal that dynein's light intermediate chains are required to maintain centrosome integrity during mitosis, preventing the premature separation of mother-daughter centrioles and the formation of multipolar spindles. This biosights episode presents the paper by Jones et al. from the November 24, 2014, issue of The Journal of Cell Biology and includes...

An in-mouth wafer to treat oral cancer– Biotech’s future

submitted by: nsf

To treat oral cancer, NSF-funded small business Privo Technologies has created a platform that delivers treatments directly to the affected area. Privo develops new classes of targeted treatments, such as chemotherapy drugs, designed to be delivered through the mouth’s mucous membranes. Privo founder Manijeh Goldberg talked about her company’s research at the 2014 BIO International Convention.

biosights: October 27, 2014 - Epithelial cells make changes at the top

submitted by: JCB
The apical surfaces of polarized epithelia are covered by short, actin-rich protrusions called microvilli, but what happens to these structures when cells detach from a monolayer during development or disease is unclear. Klingner et al. reveal that non-confluent epithelial cells form longer, more dynamic microvilli on their apical surface that connect to a cortical actomyosin network. This biosights episode presents the paper by Klingner et al. from the October 13, 2014, issue of The Journal...

Microbial signature profiles of periodontally healthy and diseased patients

submitted by: apcolombo
Aim: To determine microbial profiles that discriminate periodontal health from different forms of periodontal diseases. Methods: Subgingival biofilm was obtained from patients with periodontal health (27), gingivitis (11), chronic periodontitis (35) and aggressive periodontitis (24), and analysed for the presence of >250 species/phylotypes using HOMIM. Microbial differences among groups were examined by Mann–Whitney U-test. Regression analyses were performed to determine microbial...
Authors: Talita Lourenço, Debora Heller, Carina Silva-Boghossian, Sean Cotton, Bruce Paster, Ana Paula Colombo