biosights: September 2, 2013 - Shrinking microtubules pull the centrosome into place

submitted by: JCB
When a T cell encounters a target antigen-presenting cell, it moves its centrosome to the immunological synapse that connects the two cells. Yi et al. reveal that centrosome repositioning is a biphasic process driven by the dynein-dependent capture and depolymerization of microtubules. This biosights episode presents the paper by Yi et al. from the September 2, 2013, issue of The Journal of Cell Biology and includes an interview with senior author John Hammer (NHLBI, Bethesda, MD). Produced...

Balloon Sinuplasty Surgery overview

submitted by: ChicagoENT

Balloon Sinuplasty is an effective and safe technique and may offer big relief in treating chronic sinusitis. Balloon Sinuplasty does not involve the cutting of nasal bone or tissue. The treatment normally takes less than 2 hours and often provides complete relief from chronic sinusitis.

A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen

David Bhella: The Peter Wildy Award Talk (MWV75)

submitted by: MicrobeWorld

David Bhella, Ph.D., MRC Centre for Virus Research, accepts the Peter Wildy Prize for Microbiology Education, awarded annually by the Society for General Microbiology for an outstanding contribution to microbiology education. Recorded live March 25, 2013 in Manchester, UK.

biosights: August 5, 2013 - Epithelia restored by healing waves

submitted by: JCB
Epithelial cells around the edge of a wound assemble an actomyosin cable that constricts to draw the wound closed, but the events that precede cable formation are largely unknown. Antunes et al. reveal that wounding induces a wave of actomyosin assembly and cell constriction that flows toward the wound edge to promote cable assembly and tissue repair. This biosights episode presents the paper by Antunes et al. from the July 22, 2013, issue of The Journal of Cell Biology and includes an...

Biomolecular Sensing: Endotoxin-Induced Ordering Transitions in Liquid Crystalline Droplets

submitted by: icamvid

Biomolecular Sensing: Endotoxin-Induced Ordering Transitions in Liquid Crystalline Droplets by Dr. Nicholas L. Abbott, University of Wisconsin at Madison