biosights: August 4, 2014 - Rok keeps its finger on the pulse of apical constriction

submitted by: JCB
Early in Drosophila embryogenesis, contractile pulses of myosin assembly and disassembly constrict the apical domains of a group of epithelial cells to drive their invagination into a ventral furrow. Vasquez et al. reveal that Rho kinase and myosin phosphatase dynamically regulate these myosin pulses and that the stepwise constriction resulting from this helps maintain tissue integrity during epithelial invagination. This biosights episode presents the paper by Vasquez et al. from the August...

HERESY AND MEDICINE IN THE MIDDLE AGES

submitted by: camdic

"I fought a lot; I thought I could win, but fate and nature repressed my study and my efforts. But it is already something to be on the battlefield, because to win depends very much on fortune. But I did as much as I could, and I do not think anyone, of the future generation, will deny it. I was not afraid of death, I never gave in to anyone, I chose courageous death instead of a coward’s life". Giordano Bruno, De Monade (1591).

Stephen Quake at the 2014 DOE JGI Genomics of Energy & Environment Meeting

submitted by: JGI

Steve Quake, Stanford University, at the 9th Annual Genomics of Energy & Environment Meeting on March 18, 2014 in Walnut creek, Calif.

Gerald Tuskan at the 2014 DOE JGI Genomics of Energy & Environment Meeting

submitted by: JGI

Gerald Tuskan, Oak Ridge National Laboratory, at the 9th Annual Genomics of Energy & Environment Meeting on March 20, 2014 in Walnut Creek, Calif.

Rytas Vilgalys at the 2014 DOE JGI Genomics of Energy & Environment Meeting

submitted by: JGI

Rytas Vilgalys, Duke University, speaking at the 9th Annual Genomics of Energy & Environment Meeting on March 19, 2014 in Walnut Creek, Calif.

biosights: July 7, 2014 - The fluid dynamics of collective cell migration

submitted by: JCB
During development and tumor metastasis, cells prepare to migrate by undergoing an epithelial-to-mesenchymal transition that loosens their connections to neighboring cells. But some cell types then migrate en masse to their final destinations, indicating that their intercellular adhesions aren't disrupted completely. Kuriyama et al. reveal that the phospholipid lysophosphatidic acid promotes the collective migration of Xenopus neural crest cells by downregulating the surface expression of...