Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial

submitted by: efung
BACKGROUND: Patients with thalassemia major (Thal) frequently have low plasma zinc, which has been associated with low bone mass. OBJECTIVE: The objective was to determine the effect of zinc supplementation on bone mass in patients with Thal. DESIGN: Forty-two subjects (21 females aged 10-30 y) with Thal and low bone mass were randomly assigned to receive 25 mg Zn/d or placebo. Bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed by using dual-energy X-ray...
Authors: Ellen B. Fung, Janet L. Kwiatkowski, James N. Huang, Ginny Gildengorin, Janet C. King, Elliott P. Vichinsky

A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

submitted by: enphpdom
Background: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season. Objective: The objective was to understand the seasonality of DNA methylation patterns in rural Gambian women. We studied natural...
Authors: P Dominguez-Salas, AM Prentice

Objective Assessment of Obesogenic Environments in Youth: Geographic Information System Methods and Spatial Findings from the Neighborhood Impact on Kids Study

submitted by: Lawrence Frank
Background GIS-based walkability measures designed to explain active travel fail to capture “playability” and proximity to healthy food. These constructs should be considered when measuring potential child obesogenic environments. Purpose The aim of this study was to describe the development of GIS-based multicomponent physical activity and nutrition environment indicators of child obesogenic environments in the San Diego and Seattle regions. Methods Block group–level...
Authors: Lawrence Frank, Brian E. Saelens, James Chapman, James Sallis, Jacqueline Kerr, Karen Glanz, Sarah C. Couch, Vincent Learnihan, Chuan Zhou, Trina Colburn, Kelli L. Cain

Social Media Delivered Sexual Health Intervention: A Cluster Randomized Controlled Trial

submitted by: sheana
Design: Cluster randomized trial; data collected in 2010-2011; analyzed in 2011-2012 Setting/Participants: Individuals (seeds) recruited in multiple settings (online, via newspaper ads and face-to-face) who were asked to recruit up to three friends, who in turn recruited additional friends, extending three waves from the seed. Seeds and waves of friends were considered networks and exposed to either intervention or control condition. Intervention: Exposure to Just/Us, a Facebook page...
Authors: Sheana Bull, Deborah Levine, Sandra Black, Sarah Schmiege, John Santelli

Science Nation - Sounds of Survival

submitted by: nsf

They are quiet as church mice ... or are they? See how eavesdropping on mice provides clues about how humans process sound.

Science Nation - If These Teeth Could Talk

submitted by: nsf
With funding from the National Science Foundation, Peter Ungar is revealing more details about the lives of our human ancestors, and he's doing it through dentistry - sort of! The University of Arkansas anthropologist uses high tech dental scans to find out more about the diets of hominids, a technique that sometimes leads to new and very different conclusions. While anthropologists traditionally determine the diets of our ancestors by examining the size and shape of teeth and jaws, Ungar's...

Nonpungent capsaicin analogs (capsinoids) increase energy expenditure

submitted by: Yoneshiro
Background: Capsinoids—nonpungent capsaicin analogs—are known to activate brown adipose tissue (BAT) thermogenesis and whole-body energy expenditure (EE) in small rodents. BAT activity can be assessed by [18F]fluorodeoxyglucose–positron emission tomography (FDG-PET) in humans. Objectives: The aims of the current study were to examine the acute effects of capsinoid ingestion on EE and to analyze its relation to BAT activity in humans. Design: Eighteen healthy men aged 20–32 y...
Authors: Takeshi Yoneshiro, Sayuri Aita, Yuko Kawai, Toshihiko Iwanaga, Masayuki Saito

Correcting for Inflammation Changes Estimates of Iron Deficiency among Rural Kenyan Preschool Children

submitted by: ebogrant5
The assessment of iron status where infections are common is complicated by the effects of inflammation on iron indicators and in this study we compared approaches that adjust for this influence. Blood was collected in 680 children (aged 6–35 mo) and indicators of iron status [(hemoglobin (Hb), zinc protoporphyrin (ZP), ferritin, transferrin receptor (TfR), and TfR/ferritin index)] and subclinical inflammation [(the acute phase proteins (APP) C-reactive protein (CRP), and a-1-acid...
Authors: Frederick Grant, Parminder Suchdev, Rafael Flores-Ayala, Conrad Cole, Usha Ramakrishnan, Laird Ruth, Reynaldo Martorell

Demo: Variation for the ZAP70 gene with Ensembl

submitted by: gspudich

We use the Ensembl genome browser at www.ensembl.org to view small scale sequence variants such as SNPs (single nucleotide polymorphims) along with larger structural variations like CNVs (copy number variation) for the human ZAP70 gene.