Cellular and Functional Optical Coherence Tomography of the Human Retina (The Cogan Lecture)

submitted by: arvojenny
An imaging modality that allows for fast, simultaneous, noninvasive probing of both three-dimensional (3D) cellular resolution retinal morphology and depth-resolved function could substantially improve the early diagnosis of various retinal diseases that are the leading causes of blindness worldwide and could contribute to a better understanding of retinal pathogenesis and enhanced therapy monitoring. In addition to user friendliness, reliability, and cost, the key technological parameters...
Authors: Wolfgang Drexler

Examining 'Food Culture' for Grassroots Mobilization

submitted by: rlee

My postercast provides an overview of my thesis on the food culture of City Heights, which includes the purpose of my research, findings/analysis, and an explanation to how the knowledge that is gathered from my thesis could contribute to grassroots mobilization.

Transfected Lysate (Native)

submitted by: abnova

Abnova - Transfected lysate is useful as a positive control in Western Blot. The full-length protein construct is expressed in HEK293T cells and prepared as ready-to-use, native lysate in modified RIPA Buffer. For more videos, visit Abnova!

Acute Ingestion of Long-Chain (n-3) Polyunsaturated Fatty Acids Decreases Fibrinolysis in Men with Metabolic Syndrome

submitted by: lrobinson
Individuals with metabolic syndrome (MetS) often have elevated plasma plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA), contributing to an increased risk of cardiovascular disease. PAI-1 and t-PA may be affected by chronic (n-3) long-chain PUFA [(n-3)LCPUFA] supplementation; however, the acute impact of fat ingestion on these risk factors has not been established. Our objective was to investigate the acute effect of (n-3)LCPUFA on plasma PAI-1, t-PA, and...
Authors: Camilla Montegaard, Hilary Tulk, Lotte Lauritzen, Tine Tholstrup, Lindsay e Robinson

Tree of Life

submitted by: Treeoflife
Explore the evolutionary links between living things with the Wellcome Trust's Tree of Life, developed as part of our Darwin 200 activities, which celebrate the 200th anniversary of Charles Darwin's birth. This six-minute Tree of Life video also appeared on the BBC One programme 'Charles Darwin and the Tree of Life' narrated by David Attenborough. In addition to the video, an interactive version of the 'Tree of Life' here ( http://www.wellcometreeoflife.org ) has been created to allow...

The R403Q Myosin Mutation Implicated in Familial Hypertrophic Cardiomyopathy Causes Disorder at the Actomyosin Interface

submitted by: apryl
Background Mutations in virtually all of the proteins comprising the cardiac muscle sarcomere have been implicated in causing Familial Hypertrophic Cardiomyopathy (FHC). Mutations in the β-myosin heavy chain (MHC) remain among the most common causes of FHC, with the widely studied R403Q mutation resulting in an especially severe clinical prognosis. In vitro functional studies of cardiac myosin containing the R403Q mutation have revealed significant changes in enzymatic and...
Authors: Dorit Hanein, Larnele Hazelwood, Susan Lowey, HongJun Lui, Kathleen M. Trybus, Niels Volkmann

Bioinformatic analyses of mammalian 5'-UTR sequence properties of mRNAs predicts alternative translation initiation sites

linked profile(s): jwegrzyn
submitted by: apryl
Background Utilization of alternative initiation sites for protein translation directed by non-AUG codons in mammalian mRNAs is observed with increasing frequency. Alternative initiation sites are utilized for the synthesis of important regulatory proteins that control distinct biological functions. It is, therefore, of high significance to define the parameters that allow accurate bioinformatic prediction of alternative translation initiation sites (aTIS). This...
Authors: Jill l Wegrzyn, Thomas m Drudge, Faramarz Valafar, Vivian Hook

Rabbit Models for Alzheimer's Disease

submitted by: alex01

Diana Woodruff-Pak (Temple University, Philadelphia, PA) used cholesterol-fed rabbits as a model of AD for evaluation of currently available and potential anti-Alzheimer drugs. These animals developed typical Alzheimer pathology, including behavioral changes and deposition of ß-amyloid and even
tau. Galantamine and donepezil partially protected animals from Alzheimer symptomatology.

Cannabinoids

submitted by: alex01
Daniele Piomelli, PhD. - Another approach was discussed by D. Piomelli (University of California, Irvine). URB 597, an inhibitor of fatty acid amide hydrolase (FAAH), is expected to increase anandamide signaling and is being currently clinically tested in the therapy of pain. An increase in anandamide signaling may also be useful in the therapy of depression. This is a novel approach to the development of antidepressants. The signaling can be enhanced by blocking anadamide metabolism or by...

Bacterial Inclusion Bodies Contain Amyloid-Like Structure

linked profile(s): Lei Wang
submitted by: apryl
Protein aggregation is a process in which identical proteins self-associate into imperfectly ordered macroscopic entities. Such aggregates are generally classified as amorphous, lacking any long-range order, or highly ordered fibrils. Protein fibrils can be composed of native globular molecules, such as the hemoglobin molecules in sickle-cell fibrils, or can be reorganized β-sheet–rich aggregates, termed amyloid-like fibrils. Amyloid fibrils are associated with several...
Authors: David Eisenberg, Samir K Maji, Roland Riek, Michael R Sawaya, Lei Wang