Talk by Lim

submitted by: dougramsey

Lecturer Lim leads a discussion on the Science of Learning Centers sponsored by the National Science Foundation, what they do, what are their purpose and goals, and how they are implemented in assisting a new generation of individuals expand their education and build on it.

Talk by Eric Jensen

submitted by: dougramsey

Eric Jensen talks about the importance of scientist-educator conventions and of studies regarding the correlation of socialization to learning.

Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors

submitted by: Michael Baker
Background The glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) evolved from a common ancestor. Still not completely understood is how specificity for glucocorticoids (e.g. cortisol) and mineralocorticoids (e.g. aldosterone) evolved in these receptors. Results Our analysis of several vertebrate GRs and MRs in the context of 3D structures of human GR and MR indicates that with the exception of skate GR, a cartilaginous fish, there is a...
Authors: Michael e Baker, Charlie Chandsawangbhuwana, Noah Ollikainen

Food Insufficiency Is Associated with High-Risk Sexual Behavior among Women in Botswana and Swaziland

submitted by: jeveleth
Background Both food insufficiency and HIV infection are major public health problems in sub-Saharan Africa, yet the impact of food insufficiency on HIV risk behavior has not been systematically investigated. We tested the hypothesis that food insufficiency is associated with HIV transmission behavior. Methods and Findings We studied the association between food insufficiency (not having enough food to eat over the previous 12 months) and inconsistent...
Authors: Sheri d Weiser, Karen Leiter, David r Bangsberg, Lisa m Butler, Fiona percy-de Korte, Zakhe Hlanze, Nthabiseng Phaladze, Vincent Iacopino, Michele Heisler

Stability of response characteristics of a Delphi panel: application of bootstrap data expansion

submitted by: rakins
Background Delphi surveys with panels of experts in a particular area of interest have been widely utilized in the fields of clinical medicine, nursing practice, medical education and healthcare services. Despite this wide applicability of the Delphi methodology, there is no clear identification of what constitutes a sufficient number of Delphi survey participants to ensure stability of results. Methods The study analyzed the response characteristics...
Authors: Ralitsa b Akins, Homer Tolson, Bryan r Cole

Adaptation to Human Populations Is Revealed by Within-Host Polymorphisms in HIV-1 and Hepatitis C Virus

submitted by: art
CD8+ cytotoxic T-lymphocytes (CTLs) perform a critical role in the immune control of viral infections, including those caused by human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). As a result, genetic variation at CTL epitopes is strongly influenced by host-specific selection for either escape from the immune response, or reversion due to the replicative costs of escape mutations in the absence of CTL recognition. Under strong CTL-mediated selection, codon positions...
Authors: Art f. y Poon, Sergei l. kosakovsky Pond, Phil Bennett, Douglas d Richman, Andrew j. leigh Brown, Simon d. w Frost

Amazing Earth 2

submitted by: scivee-team

A documentary about volcanic eruptions, their causes and effects on Earth and the geological implications of those events in history and in the future - Part 2.

Pericardial pathology 900 years ago: A study and translations from an Arabic medical textbook

submitted by: rabie
This is a study and translation of the section on pericarditis in Al Taisir book written by the Muslim physician Ibn Zuhr (Avenzoar) who lived and practiced in Eshbeelia (nowadays Seville, Andalusia, Spain) between 1091-1162 AD. Ibn Zuhr described the serous type of pericarditis as well as the pathological findings in fibrinous pericarditis. His description of the latter may also fit with the picture of chronic fibrous pericarditis. He also described acute purulent pericarditis and...
Authors: Rabie e. Abdel-halim, Salah r. Elfaqih, Frcs Ed

Wiggle—Predicting Functionally Flexible Regions from Primary Sequence

submitted by: jgu
The Wiggle series are support vector machine–based predictors that identify regions of functional flexibility using only protein sequence information. Functionally flexible regions are defined as regions that can adopt different conformational states and are assumed to be necessary for bioactivity. Many advances have been made in understanding the relationship between protein sequence and structure. This work contributes to those efforts by making strides to understand the relationship...
Authors: Jenny Gu, Michael Gribskov, Philip E Bourne

Structural Evolution of the Protein Kinase–Like Superfamily

linked profile(s): Phil
submitted by: escheeff
The protein kinase family is large and important, but it is only one family in a larger superfamily of homologous kinases that phosphorylate a variety of substrates and play important roles in all three superkingdoms of life. We used a carefully constructed structural alignment of selected kinases as the basis for a study of the structural evolution of the protein kinase–like superfamily. The comparison of structures revealed a “universal core” domain consisting only of...
Authors: Eric d Scheeff, Philip e Bourne