Apicomplexan Parasites, Pathogen Genome Informatics, and the Evolution of Eukaryotic Organelles by David S. Roos, May 2008 - Part 1: How to build a parasite

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There are more than 5000 species of single-celled eukaryotes in the biological phylum known as the Apicomplexa, including the parasites responsible for malaria, neurological birth defects, and opportunistic infections associated with HIV/AIDS. These ancient protozoa provide a unique window into the evolution of subcellular organelles that have long fascinated cell biologists. Familiar features help to elucidate the origins, functions and design parameters for the secretory pathway,...