Association between prenatal polychlorinated biphenyl exposure and obesity development at ages 5 and 7y: a prospective cohort study of 656 children from the Faroe Islands

submitted by: jltp@mac.com
Abstract Background: Chemicals with endocrine-disrupting abilities may act as obesogens and interfere with the body's natural weight-control mechanisms, especially if exposure occurs during prenatal life. Objective: We examined the association between prenatal exposure to polychlorinated biphenyls (PCBs) and p,p?-dichlorodiphenyldichloroethylene (DDE) and subsequent obesity at 5 and 7 y of age. Design: From 1997 to 2000, 656 pregnant Faroese women were recruited. PCB and DDE were...
Authors: Jeanett L Tang-Péronard, Berit L Heitmann, Helle R Andersen, Ulrike Steuerwald, Philippe Grandjean, Pál Weihe, Tina K Jensen

Silencing the Menkes Copper-Transporting ATPase (Atp7a) Gene in Rat Intestinal Epithelial (IEC-6) Cells Increases Iron Flux via Transcriptional Induction of Ferroportin 1 (Fpn1)

submitted by: jfcollins
The Menkes copper-transporting ATPase (Atp7a) gene is induced in rat duodenum during iron deficiency, consistent with copper accumulation in the intestinal mucosa and liver. To test the hypothesis that ATP7A influences intestinal iron metabolism, the Atp7a gene was silenced in rat intestinal epithelial (IEC-6) cells using short hairpin RNA (shRNA) technology. Perturbations in intracellular copper homeostasis were noted in knockdown cells, consistent with the dual roles of ATP7A in pumping...
Authors: Sukru Gulec, James F. Collins

DIETARY MAGNESIUM INTAKE IS INVERSELY ASSOCIATED WITH MORTALITY IN ADULTS AT HIGH CARDIOVASCULAR RISK

submitted by: Marta Guasch
The relation between dietary magnesium intake and cardiovascular disease or mortality has been evaluated in several prospective studies, but few of them have assessed the risk of all-cause mortality, which has never been evaluated in Mediterranean adults at high cardiovascular risk. The aim of this study was to assess the association between magnesium intake and cardiovascular disease and mortality risk, in a Mediterranean population at high cardiovascular risk with high average magnesium...
Authors: Marta Guasch-Ferré, Mònica Bulló, Ramon Estruch, Dolores Corella, Miguel A Martínez-González, Emilio Ros, Maribel Covas, Fernando Arós, Enrique Gómez-Gracia, Miquel Fiol, José Lapetra, Miguel A Muñoz, Lluís Serra-Majem, Nancy Babio, Xavier Pintó, Rosa M Lamuela-Raventós, Valentina Ruiz-Gutíerrez, Jordi Salas-Salvadó

Polymorphisms in genes involved in folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia

submitted by: LUCIANA TOMITA
High folate intake has been suggested as an important factor for cancer prevention; however, previous studies on the relationship between folate intake, serum folate and plasma homocysteine are controversial. We conducted a hospital-based, case-control study in Brazil investigating associations between dietary and circulating vitamins B-6, B-12 and folate, homocysteine, genotypes of folate-metabolizing enzyme methylenetetrahydrofolate reductase [MTHFR C677T, A1298C],...
Authors: Luciana Tomita, Vania d'Almeida, Luisa Villa, Eduardo Franco, Marly Cardoso

Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial

submitted by: efung
BACKGROUND: Patients with thalassemia major (Thal) frequently have low plasma zinc, which has been associated with low bone mass. OBJECTIVE: The objective was to determine the effect of zinc supplementation on bone mass in patients with Thal. DESIGN: Forty-two subjects (21 females aged 10-30 y) with Thal and low bone mass were randomly assigned to receive 25 mg Zn/d or placebo. Bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed by using dual-energy X-ray...
Authors: Ellen B. Fung, Janet L. Kwiatkowski, James N. Huang, Ginny Gildengorin, Janet C. King, Elliott P. Vichinsky

Belief beyond the evidence: using the presumed effect of breakfast on obesity

submitted by: awbrown
Background: Various intentional and unintentional factors in?uence beliefs beyond what scienti?c evidence justi?es. Two such factors are research lacking probative value (RLPV) and biased research reporting (BRR). Objective: We investigated the prevalence of RLPV and BRR in research about the proposition that skipping breakfast causes weight gain, which is called the proposed effect of breakfast on obesity (PEBO) in this article. Design: Studies related to the PEBO were synthesized...
Authors: David Allison, Michelle Bohan Brown, Andrew Brown

A health promotion intervention can affect diet quality in early childhood

Initiatives to promote childrens nutrition and prevent childhood obesity are vital. Dietary patterns are a useful way to characterize whole diets, though no previous early childhood health promotion trial to our knowledge has assessed intervention impact using this approach. This research aimed to assess the effect of a healthy eating and physical activity intervention on young childrens dietary patterns. The Melbourne Infant Feeding Activity and Nutrition Trial Program was a health...
Authors: Alison Spence, Sarah McNaughton, Sandrine Lioret, Kylie Hesketh, David Crawford, Karen Campbell

Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis

submitted by: vmalik
Background: The relation between sugar-sweetened beverages (SSBs) and body weight remains controversial. Objective: We conducted a systematic review and meta-analysis to summarize the evidence in children and adults. Design: We searched PubMed, EMBASE, and Cochrane databases through March 2013 for prospective cohort studies and randomized controlled trials (RCTs) that evaluated the SSB-weight relation. Separate meta-analyses were conducted in children and adults and for cohorts and...
Authors: Vasanti Malik, An Pan, Walter Willett, Frank Hu

Effects of vitamin C and D administration on mood and distress in acutely hospitalized patients

submitted by: LJHOFFER
Background: Hypovitaminosis C and D are highly prevalent in acute-care hospitals. Malnutrition with regard to these vitamins has been linked to mood disturbance and cognitive dysfunction. Objective: To determine whether vitamin C or D supplementation improves mood state or reduces psychological distress in acutely hospitalized patients with a high prevalence of hypovitaminosis C and D. Methods: Randomized, double-blind, active-control clinical trial comparing the effect of vitamin C (500...
Authors: Yifan Yang, Xing Jian Liu, Line Robitaille, Shaun Eintracht, Elizabeth MacNamara, L. John Hoffer

A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen