Intracellular Parasitism by Trypanosoma cruzi and Leishmania: Part 2: Leishmania spp and Leishmaniasis (13:36)

submitted by: video_collector

In the second part of this lecture, I will present background material on Leishmania, the intracellular protozoan parasites responsible for severe human pathology in several parts of the world. I will discuss the main disease forms, the history of identification of the causative agent and form of transmission, and recent discoveries that established important concepts in our understanding of this increasingly serious infectious disease.

Danger from the Wild: HIV, Can We Conquer It? Part 3: The Grand Challenge: Engineering Immunity (18:51)

submitted by: video_collector
In this last segment, I describe another gene therapy strategy for HIV in which we propose to develop antibody-like proteins that can be expressed by a patient's B cells and will target the HIV virus for destruction. To achieve this objective, hematopoietic (blood) stem cells must to be targeted with the gene, which will ultimately develop into B cells that express the therapeutic molecule. The ultimate goal is to produce a life-long supply of anti-HIV neutralizing antibodies. In this...

Danger from the Wild: HIV, Can We Conquer It?": Part 2: Why Gene Therapy Might be a Reasonable Tool for Attacking HIV (30:08)"

submitted by: video_collector
In part 2, I describe the growing health problem that is facing the world with the spread of HIV and the limitations of current drug therapies and vaccine strategies. We need new ideas for tackling this problem. Here and in the next segment, I describe bold strategies of using gene therapy to conquer HIV, The approach that I describe in this segment involves gene therapy to produce short hairpin RNAs (siRNA) that target the destruction of a critical co-receptor of HIV, which the viruses that...

Plant Viruses and Crops ": Part 2: Genetic Engineering for Virus Resistance in Plants: Different Viruses Demand Different Strategies (01:02:11) "

submitted by: video_collector

The second part of the lecture will relate how this information can be used to produce crops resistant to specific viruses through different biotechnology strategies.

For further information see: http://www.ascb.org/ibioseminars/Beachy/Beachy1.cfm

Apicomplexan Parasites, Pathogen Genome Informatics, and the Evolution of Eukaryotic Organelles: Part 3C: Designing and mining pathogen genome databases: From genes to drugs and vaccines (25:45)

submitted by: video_collector
With the emergence of genomic-scale datasets representing all of the genes in the genome, all of the proteins in a cell or tissue, and all of the interactions and signals in an organism, biologists are increasingly faced with the challenge of how to store, integrate, and interrogate this information. How can we effectively mine large-scale datasets to expedite biological discovery, for example in the identification of new targets for anti-parasitic drug and vaccine design? Computational...

Apicomplexan Parasites, Pathogen Genome Informatics, and the Evolution of Eukaryotic Organelles: Part 3B: Designing and mining pathogen genome databases: From genes to drugs and vaccines (27:10)

submitted by: video_collector
With the emergence of genomic-scale datasets representing all of the genes in the genome, all of the proteins in a cell or tissue, and all of the interactions and signals in an organism, biologists are increasingly faced with the challenge of how to store, integrate, and interrogate this information. How can we effectively mine large-scale datasets to expedite biological discovery, for example in the identification of new targets for anti-parasitic drug and vaccine design? Computational...

Apicomplexan Parasites, Pathogen Genome Informatics, and the Evolution of Eukaryotic Organelles: Part 3A: Designing and mining pathogen genome databases: From genes to drugs and vaccines (20:04)

submitted by: video_collector
With the emergence of genomic-scale datasets representing all of the genes in the genome, all of the proteins in a cell or tissue, and all of the interactions and signals in an organism, biologists are increasingly faced with the challenge of how to store, integrate, and interrogate this information. How can we effectively mine large-scale datasets to expedite biological discovery, for example in the identification of new targets for anti-parasitic drug and vaccine design? Computational...

Apicomplexan Parasites, Pathogen Genome Informatics, and the Evolution of Eukaryotic Organelles: Part 2: The apicomplexan plastid: Something old, something new, something borrowed, something green (37:11)

submitted by: video_collector
Antibiotics are effective because they kill bacteria without harming humans and other eukaryotes (organisms with cells that contain nuclei). So why are the eukaryotic parasites responsible for malaria and toxoplasmosis killed by drugs like clindamycin? Multidisciplinary studies integrating molecular genetics, cell biology, biochemistry, pharmacology and computational genomics reveal that such drugs target an unusual organelle. The "apicoplast" was acquired when an ancestral organism 'ate' a...

Electromicrobiology: Novel Approaches for Investigating Charge Transfer and Energy Transformation in Microbial Systems

submitted by: dougramsey
Respiratory microorganisms capture energy for growth and maintenance as they transfer electrons from energy sources to appropriate electron acceptors. Controlling the availability of electron donor and acceptor pairs provides opportunities for investigating fundamental aspects of energy transformation and distribution in defined and un defined microbial cultures. For example, we have noted that in all bacteria investigated to date electron acceptor limitation prompts the production of...

The Symmetry of Uracil Translated into a Model Energy Genealogy

submitted by: hsrikm
Though synthesis of Uracil is not possible to accomplish from its' naturally apparent parts it is physically divisible into two symmetrical fragments that are mirror images of one another. A model is presented in animated form that associates a transparent energy divide to this situation as a basic universal parity that enables the existence of the cell as a genetic transmission, relates nucleic acid structure to a transparent energy scale that is based distances along a mobius...