Changes in Erythrocyte Membrane Trans and Marine Fatty Acids between 1999 and 2006 in Older Americans.

submitted by: jpolreis
Over the last several years, national programs to lower the content of industrially produced (IP) C18:1 and C18:2 trans fatty acids in foods have been implemented, but whether this has resulted in lower blood trans fatty acid levels is unknown. Likewise, an increased perception of the health benefits of fish oils rich in EPA and DHA may have resulted in an increase in consumption and blood levels of these fatty acids. To explore these issues, we analyzed the changes in RBC fatty acid...
Authors: WS Harris, JV Pottala

The Obesity Paradox, Cardiorespiratory Fitness, and Coronary Heart Disease

submitted by: WentzMR

Dr. Carl (Chip) Lavie, a cardiologist from Ochsner Clinic in New Orleans, LA, discusses an article appearing in the May 2012 issue of Mayo Clinic Proceedings, which provides further evidence for the validation of the obesity paradox. Previous study results may be misleading if fitnessof the patient is not also considered.
Available at: http://www.mayoclinicproceedings.org/article/S0025-6196(12)00266-2/fulltext

Beef in an Optimal Lean Diet study: effects on lipids, lipoproteins, and apolipoproteins

submitted by: mikeroussell
Background: A Step I diet with lean beef compared with lean white meat both decrease LDL cholesterol. To our knowledge, no studies have evaluated a low–saturated fatty acid (SFA) (<7% calories) diet that contains lean beef. Objective: We studied the effect on LDL cholesterol of cholesterol-lowering diets with varying amounts of lean beef [ie, Dietary Approaches to Stop Hypertension (DASH): 28 g beef/d; Beef in an Optimal Lean Diet (BOLD): 113 g beef/d; and Beef in an Optimal Lean Diet...
Authors: Michael Roussell, Alison Hill, Trent Gaugler, Sheila West, John Vanden Heuvel, Peter Gillies, Penny Kris-Etherton

Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies.

submitted by: wbgrant
Background: Low vitamin D status may increase mortality risk. OBJECTIVE: We used nonparametric ("highest compared with lowest" categories) and parametric (>2 categories) statistical models to evaluate associations of 25-hydroxyvitamin D [25(OH)D] serum concentrations and mortality in observational studies among general populations. DESIGN: We searched PubMed, EMBASE, Web of Science, and reference lists for relevant articles. We included studies that contained data on relative risks (RRs)...
Authors: Armin Zittermann, Simona Iodice, Stefan Pilz, William B. Grant, Vincenzo Bagnardi, Sara Gandini

Fasting Plasma Glucose and Risk of Stroke in Men

submitted by: mcgheekkm
Description: Dr. Carl (Chip) Lavie, Professor of Medicine in the Department of Cardiovascular Diseases at the John Ochsner Heart and Vascular Institute, Ochsner Clinical School and the University of Queensland School of Medicine in New Orleans, Louisiana, discusses his article appearing as an Online First article and in the November 2011 issue of Mayo Clinic Proceedings on the effects of hyperglycemia and risk of stroke in asymptomatic men. Available at: http://tinyurl.com/6efez5x

Dietary Ellagic Acid Attenuates Oxidized LDL Uptake and Stimulates Cholesterol Efflux in Murine Macrophages

submitted by: shpark
Foam cell formation is the hallmark of early atherosclerosis. Lipid uptake by scavenger receptors (SR) in macrophages initiates chronic proinflammatory cascades linked to atherosclerosis. It has been reported that the upregulation of cholesterol efflux may be protective in the development of atherosclerosis. Ellagic acid, a polyphenolic compound mostly found in berries, walnuts, and pomegranates, possesses antioxidative, growth-inhibiting and apoptosis-promoting activities in cancer...
Authors: Young-Hee Kang, Min-Kyung Kang, Ju-Hyun Gong, Seon-Young Han, Eun-Sook Lee, Jung-Lye Kim, Sin-Hye Park

Vitamin D intake and risk of cardiovascular disease in US men and women

submitted by: qisun
These powerpoint slides describe the background, objective, methods, main results, discussion, and conclusion of the article. Background: Although studies have linked vitamin D deficiency to an increased risk of cardiovascular disease (CVD), evidence regarding whether vitamin D intake from foods or supplements is prospectively associated with lower CVD risk in healthy humans is limited and inconclusive. Objective: The objective was to comprehensively evaluate the associations between...
Authors: Joann Manson, Frank Hu, Edward Giovanucci, Eric Rimm, Ling Shi, Qi Sun, Kathryn Rexrode

The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?

submitted by: Arne Astrup
Current dietary recommendations advise reducing the intake of saturated fatty acids (SFAs) to reduce coronary heart disease (CHD) risk, but recent findings question the role of SFAs. This expert panel reviewed the evidence and reached the following conclusions: the evidence from epidemiologic, clinical, and mechanistic studies is consistent in finding that the risk of CHD is reduced when SFAs are replaced with polyunsaturated fatty acids (PUFAs). In populations who consume a Western...
Authors: W.c. Willett, T. Tholstrup, S. Stender, A. Sinclair, T. Sanders, U. Risérus, P. Nestel, P. Legrand, J.m. Lecerf, R.m. Krauss, F.j. Kok, M.u. Jakobsen, F.b. Hu, K. Hermansen, J. Dyerberg, P. Elwood, A. Astrup

Medication Adherence: WHO Cares?

submitted by: mcgheekkm

Description: Drs Marie Brown and Jennifer Bussells, practicing internists in the Chicago, Illinois area discuss their article appearing in the April 2011 issue of Mayo Clinic Proceedings. Available at: http://tinyurl.com/6ees9ar regarding patient adherence to prescribed medications.

Introduction to the RGD Phenotypes and Models Portal

submitted by: jennifer.r.smith

Despite what our name might imply, the Rat Genome Database contains much more than just genomic and genetic data for the rat. This video will give you an overview of the RGD Phenotypes and Models portal—a rich resource of information on topics including animal husbandry, identifying what rat strains are good models for certain human diseases, and normal physiological measurements for a variety of rat strains.