biosights: July 7, 2014 - The fluid dynamics of collective cell migration

submitted by: JCB
During development and tumor metastasis, cells prepare to migrate by undergoing an epithelial-to-mesenchymal transition that loosens their connections to neighboring cells. But some cell types then migrate en masse to their final destinations, indicating that their intercellular adhesions aren't disrupted completely. Kuriyama et al. reveal that the phospholipid lysophosphatidic acid promotes the collective migration of Xenopus neural crest cells by downregulating the surface expression of...

Advanced FPGA Designs - Blue Pearl Software

submitted by: bluepearlsoftware

Blue Pearl Software Inc is an electronic design automation company that offers a unique and powerful approach to improving the process of designing computer chips or integrated circuits . Blue Pearl provides high performance, innovative, automated tools to generate and validate critical timing and functional information early in the design cycle.

Color and Uncertainty: It is not always Black and White

submitted by: alexandertoet
To fully comprehend the meaning and impact of visualized data it is crucial that users are able to perceive and comprehend the inherent uncertainty of the data in a correct and intuitive way. Data uncertainty is frequently visualized through color mappings. Previous studies argued that color hue is not suitable for communicating uncertainty because most hue scales lack an intrinsic perceptual order. In this paper we examine the use of hue for communicating data uncertainty in more detail. We...

Progress in Color Nightvision

submitted by: alexandertoet
I present a sample based color transfer method that gives nightvision imagery a realistic color appearance. The method is specific for different types of materials in a scene and can easily be adapted for the intended operating theatre and the task at hand. Because of its simplicity the method is highly suitable for real-time implementations. In this presentation I will show some nighttime movies that have been registered with prototype camera systems that apply the new color mapping...

biosights: June 9, 2014 - Rab18 tilts the balance of ER structure

submitted by: JCB
The endoplasmic reticulum consists of peripheral tubular networks connected to sheet-like domains surrounding the nucleus. Gerondopoulos et al. reveal that the Rab3GAP complex, which is mutated in the neurodevelopmental disorder Warburg Micro Syndrome, is a guanine nucleotide exchange factor that activates the small GTPase Rab18 (also mutated in Warburg Micro Syndrome) to control the balance between ER tubules and sheets. This biosights episode presents the paper by Gerondopoulos et al. from...

biosights: May 12, 2014 - Phosphoinositides get cells in shape

submitted by: JCB
Early Drosophila embryos undergo 13 rounds of rapid nuclear division before enclosing each nucleus into an individual, membrane-bound cell. Reversi et al. describe how the phosphoinositides PI(4,5)P2 and PI(3,4,5)P3 control the resulting cell shapes by coordinating actomyosin contractility with plasma membrane expansion. This biosights episode presents the paper by Reversi et al. from the May 12, 2014, issue of The Journal of Cell Biology and includes an interview with senior author Stefano...