biosights: February 16, 2015 - Filopodia point the way for haptotaxis

submitted by: JCB
Migrating fibroblasts maintain or change their direction by branching off new lamellipodia from existing protrusions at the cell's leading edge. Johnson et al. reveal that filopodial protrusions initiate and orient these lamellipodia, helping fibroblasts navigate gradients of immobilized guidance cues. This biosights episode presents the paper by Johnson et al. from the February 16, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Jason...

NSF and Popular Science announce 2015 Vizzies winners

submitted by: nsf

The Vizzies celebrates the use of visual media to clearly and accessibly communicate scientific data and research. It recognizes the finest illustrations, photographs, videos, graphics and apps, whether produced by academic researchers, artists or hobbyists.

biosights: January 19, 2015 - Tubulin transport pumps up cilia

submitted by: JCB
The assembly of cilia and flagella requires the delivery of large amounts of tubulin to the growing ends of the organelles' microtubules. Craft et al. reveal that tubulin loading onto intraflagellar transport particles is specifically upregulated in growing cilia. This biosights episode presents the paper by Craft et al. from the January 19, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Karl Lechtreck (University of Georgia, Athens, GA)....

biosights: December 22, 2014 - Osmotic gradient is just the tonic for wounded epithelia

submitted by: JCB
Rapid wound repair is generally thought to be initiated by intrinsic cues, such as changes in the structure or mechanics of damaged tissues. Gault et al. reveal that an extrinsic signal — the osmolarity of the external environment — can stimulate wound closure in zebrafish by inducing epithelial cell migration. This biosights episode presents the paper by Gault et al. from the December 22, 2014, issue of The Journal of Cell Biology and includes an interview with the paper's senior...

biosights: November 24, 2014 - Dynein helps centrioles stick together

submitted by: JCB
Dynein has numerous functions in mitosis, but the function of the motor complex's light intermediate chains is poorly understood. Jones et al. reveal that dynein's light intermediate chains are required to maintain centrosome integrity during mitosis, preventing the premature separation of mother-daughter centrioles and the formation of multipolar spindles. This biosights episode presents the paper by Jones et al. from the November 24, 2014, issue of The Journal of Cell Biology and includes...

8 BEST PHP FRAMEWORKS FOR DEVELOPING AGILE APPLICATIONS FASTER

submitted by: Deaninfotech

PHP is one of the programming languages which is rocking the development world since the last few years due to its inherent flexibility and comparatively easier learning curve. But, developing perfect agile software applications in PHP has always been a challenging and time consuming task.