biosights: June 9, 2014 - Rab18 tilts the balance of ER structure

submitted by: JCB
The endoplasmic reticulum consists of peripheral tubular networks connected to sheet-like domains surrounding the nucleus. Gerondopoulos et al. reveal that the Rab3GAP complex, which is mutated in the neurodevelopmental disorder Warburg Micro Syndrome, is a guanine nucleotide exchange factor that activates the small GTPase Rab18 (also mutated in Warburg Micro Syndrome) to control the balance between ER tubules and sheets. This biosights episode presents the paper by Gerondopoulos et al. from...

biosights: May 12, 2014 - Phosphoinositides get cells in shape

submitted by: JCB
Early Drosophila embryos undergo 13 rounds of rapid nuclear division before enclosing each nucleus into an individual, membrane-bound cell. Reversi et al. describe how the phosphoinositides PI(4,5)P2 and PI(3,4,5)P3 control the resulting cell shapes by coordinating actomyosin contractility with plasma membrane expansion. This biosights episode presents the paper by Reversi et al. from the May 12, 2014, issue of The Journal of Cell Biology and includes an interview with senior author Stefano...

Проповедь Франциска Ассизского птицам. Смысл, который придавал ей сам Святой и восприятие ее современниками (на основе письменных источников XIII века и ранней иконографии этой проповеди XIII-XV веков).

submitted by: khlopov55
Костыря Виктория Александровна Исследовательская работа на тему: Проповедь Франциска Ассизского птицам. Смысл, который придавал ей сам Святой и восприятие ее современниками (на основе письменных источников XIII века и ранней иконографии этой проповеди XIII-XV веков)....

biosights: April 14, 2014 - An actin lever flattens out the cell

submitted by: JCB
The lamella is a broad, flat region that forms at the front of migrating cells and adheres to the underlying substrate. Burnette et al. reveal that cells flatten out the lamella by mechanically coupling a contractile actomyosin network at the dorsal surface to ventral cell adhesions. This biosights episode presents the paper by Burnette et al. from the April 14, 2014, issue of The Journal of Cell Biology and includes an interview with authors Dylan Burnette (Vanderbilt University School of...

Can you still exercise when you have cancer?

submitted by: mdanderson
Is it safe to exercise when you have cancer? Are there specific exercises that should be avoided or are there warning signs to stop your workout? Whether you’re an athlete or have never exercised, this advice is for the cancer patient/survivor who wants to increase longevity through exercise. Carol Harrison, senior exercise physiology technologist at MD Anderson Cancer Center, offers suggestions and shares information to help cancer survivors stay on track with their exercise programs.

biosights: March 17, 2014 - Blebs lead the way in Dictyostelium chemotaxis

submitted by: JCB
Membrane blebs can help the leading edge of migrating cells protrude forwards, but the contribution of blebs to the motility of Dictyostelium cells is unclear. Zatulovskiy et al. reveal that blebs form at the front of chemotaxing Dictyostelium cells, particularly when the cells are faced with a mechanically resistant environment, and that this process is guided by a PI3-kinase-dependent signaling pathway. This biosights episode presents the paper by Zatulovskiy et al. from the March 17,...