Cost-effectiveness of non-surgical peri-implantitis treatments

submitted by: slistl
Aim: The purpose of the present study was to assess the cost-effectiveness of various alternatives of non-surgical peri-implantitis treatment. Materials and Methods: A decision analytical model was constructed and populated with parameter estimates from recent literature for reduction in pocket probing depth (PPD) in response to eight different treatment alternatives. A micro-costing approach combined with an online expert survey was applied to simulate a decision-making scenario taking...
Authors: Stefan Listl, Nadine Frühauf, Bettina Dannewitz, Christiane Weis, Yu-Kang Tu, Huei-Ju Chang, Clovis Faggion

biosights: May 11, 2015 - Formin' actin at adherens junctions

submitted by: JCB
Actin assembly promotes the formation of intercellular adherens junctions, but the role of actin-nucleating formin proteins in this process remains unclear. Grikscheit et al. reveal that, in breast epithelial cells cultured in 3D, the formin FMNL2 stimulates junctional actin assembly downstream of the small GTPase Rac1. This biosights episode presents the paper by Grikscheit et al. from the May 11, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior...

biosights: April 13, 2015 - A motif that helps myosin II-B lead from behind

submitted by: JCB
Myosin II-A and myosin II-B play distinct roles in establishing the front–back polarity of migrating mesenchymal cells. Juanes-Garcia et al. identify a short, serine-rich motif in the non-helical tail domain of myosin II-B that enables this isoform to form stable actomyosin bundles that define the cell rear. This biosights episode presents the paper by Juanes-Garcia et al. from the April 13, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior...

biosights: March 16, 2015 - PAPC separates tissues at a Snail's pace

submitted by: JCB
Brachet's cleft separates the ectoderm and mesoderm of early Xenopus and zebrafish embryos. Luu et al. reveal that, in conjunction with the transcription factor Snail1, the protocadherin PAPC promotes tissue separation by down-regulating planar cell polarity proteins at the ectoderm-mesoderm boundary. This biosights episode presents the paper by Luu et al. from the March 16, 2015, issue of The Journal of Cell Biology and includes an interview with one of the paper's senior authors, Rudolf...

biosights: February 16, 2015 - Filopodia point the way for haptotaxis

submitted by: JCB
Migrating fibroblasts maintain or change their direction by branching off new lamellipodia from existing protrusions at the cell's leading edge. Johnson et al. reveal that filopodial protrusions initiate and orient these lamellipodia, helping fibroblasts navigate gradients of immobilized guidance cues. This biosights episode presents the paper by Johnson et al. from the February 16, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior author, Jason...

NSF and Popular Science announce 2015 Vizzies winners

submitted by: nsf

The Vizzies celebrates the use of visual media to clearly and accessibly communicate scientific data and research. It recognizes the finest illustrations, photographs, videos, graphics and apps, whether produced by academic researchers, artists or hobbyists.