biosights: October 27, 2014 - Epithelial cells make changes at the top

submitted by: JCB
The apical surfaces of polarized epithelia are covered by short, actin-rich protrusions called microvilli, but what happens to these structures when cells detach from a monolayer during development or disease is unclear. Klingner et al. reveal that non-confluent epithelial cells form longer, more dynamic microvilli on their apical surface that connect to a cortical actomyosin network. This biosights episode presents the paper by Klingner et al. from the October 13, 2014, issue of The Journal...

Community College Innovation Challenge

submitted by: nsf

The National Science Foundation announces its Community College Innovation Challenge. The contest challenges community college students to propose innovative STEM-based (science, technology, engineering and mathematics) solutions to perplexing, real-world problems. Teams submitting top ideas receive professional coaching and cash prizes.

Cognitive Heart Failure explained via 3D Animation

submitted by: Scientific Animations

CHF or Congestive Heart Failure, a condition on continuos rise explained - Are lifestyle changes responsible for increase in cases of CHF? What are the main causes? Economic impact on health system? Innovations in diagnosing and treating CHF?
Medical Industry Trends for CHF

biosights: September 29, 2014 - Cdc42 prompts a change of heart

submitted by: JCB
The Drosophila heart is a simple tubular structure with a central lumen. Vogler et al. reveal that the small GTPase Cdc42 and actin-nucleating formin proteins promote lumen formation by regulating the dynamics of non-muscle myosin in cardioblasts during heart morphogenesis. This biosights episode presents the paper by Vogler et al. from the September 29, 2014, issue of The Journal of Cell Biology and includes an interview with two of the paper's authors, Georg Vogler and Rolf Bodmer...

biosights: September 1, 2014 - Deploying exosomes in a battle of the sexes

submitted by: JCB
The paired accessory glands of male Drosophila secrete multiple signaling factors into the seminal fluid that promote reproductive success by altering the recipient female's physiology and behavior. Corrigan et al. reveal that the secondary cells of accessory glands secrete membrane-bound exosomes in a BMP-dependent manner that, after being transferred into the female reproductive tract, inhibit the female's inclination to re-mate with other male flies. This biosights episode presents the...

biosights: August 4, 2014 - Rok keeps its finger on the pulse of apical constriction

submitted by: JCB
Early in Drosophila embryogenesis, contractile pulses of myosin assembly and disassembly constrict the apical domains of a group of epithelial cells to drive their invagination into a ventral furrow. Vasquez et al. reveal that Rho kinase and myosin phosphatase dynamically regulate these myosin pulses and that the stepwise constriction resulting from this helps maintain tissue integrity during epithelial invagination. This biosights episode presents the paper by Vasquez et al. from the August...