biosights: July 6, 2015 - Interphase centrosomes flare up

submitted by: JCB
Centrosomes undergo dramatic changes in size and structure during the rapid cell cycles of early Drosophila embryos. Lerit et al. reveal that a scaffold formed by the proteins centrosomin and PLP is required to maintain the activity of interphase centrosomes, which is essential for nuclear spacing and proper chromosome segregation. This biosights episode presents the paper by Lerit et al. from the July 6th, 2015, issue of The Journal of Cell Biology and includes an interview with two of the...

Apical periodontitis and incident cardiovascular events in the Baltimore Longitudinal Study of Ageing

submitted by: endomax
Aim: To evaluate whether the presence of apical periodontitis (AP), root canal treatment (RCT) and endodontic burden (EB) – as the sum of AP and RCT sites – were associated with long-term risk of incident cardiovascular events (CVE), including cardiovascular-related mortality, using data on participants in the Baltimore Longitudinal Study of Ageing (BLSA). Methodology: This retrospective cohort included 278 dentate participants in the BLSA with complete medical and dental examinations....
Authors: Maximiliano Gomes, Fernando Hugo, Juliana Hilgert, Manoel Sant´Ana Filho, Dalva Padilha, Eleanor Simonsick, Luigi Ferrucci, Mark Reynolds

biosights: June 8, 2015 - Melanosomal cargoes BLOC'd off from alternate routes

submitted by: JCB
The BLOC-2 complex contains three subunits encoded by genes mutated in Hermansky-Pudlak syndrome, a disease caused by defects in the trafficking pathways that form melanosomes and other lysosome-related organelles. Dennis et al. reveal that the BLOC-2 complex promotes the delivery of melanosomal cargo by targeting recycling endosomal tubules to maturing melanosomes. This biosights episode presents the paper by Dennis et al. from the May 25, 2015, issue of The Journal of Cell Biology and...

Запах женщины. Духи как способ выживания. Системно-векторная психология Юрия Бурлана - svp

submitted by: svp
Духи это для женщины все! Молекулы духов, как вертолетики... подсаживают на себя наши тяжелые феромоны... помогают не затеряться и найти своего идеального партнера на просторах большого города... Оригинал здесь:

Cost-effectiveness of non-surgical peri-implantitis treatments

submitted by: slistl
Aim: The purpose of the present study was to assess the cost-effectiveness of various alternatives of non-surgical peri-implantitis treatment. Materials and Methods: A decision analytical model was constructed and populated with parameter estimates from recent literature for reduction in pocket probing depth (PPD) in response to eight different treatment alternatives. A micro-costing approach combined with an online expert survey was applied to simulate a decision-making scenario taking...
Authors: Stefan Listl, Nadine Frühauf, Bettina Dannewitz, Christiane Weis, Yu-Kang Tu, Huei-Ju Chang, Clovis Faggion

biosights: May 11, 2015 - Formin' actin at adherens junctions

submitted by: JCB
Actin assembly promotes the formation of intercellular adherens junctions, but the role of actin-nucleating formin proteins in this process remains unclear. Grikscheit et al. reveal that, in breast epithelial cells cultured in 3D, the formin FMNL2 stimulates junctional actin assembly downstream of the small GTPase Rac1. This biosights episode presents the paper by Grikscheit et al. from the May 11, 2015, issue of The Journal of Cell Biology and includes an interview with the paper's senior...