Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial

submitted by: efung
BACKGROUND: Patients with thalassemia major (Thal) frequently have low plasma zinc, which has been associated with low bone mass. OBJECTIVE: The objective was to determine the effect of zinc supplementation on bone mass in patients with Thal. DESIGN: Forty-two subjects (21 females aged 10-30 y) with Thal and low bone mass were randomly assigned to receive 25 mg Zn/d or placebo. Bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed by using dual-energy X-ray...
Authors: Ellen B. Fung, Janet L. Kwiatkowski, James N. Huang, Ginny Gildengorin, Janet C. King, Elliott P. Vichinsky

Penile cancer basics

submitted by: mdanderson
Download from iTunes: https://itunes.apple.com/us/itunes-u/penile-cancer-basics/id431848216?i=... . Penile cancer is rare with less than 2,000 men being diagnosed in the US each year and around 26,000 worldwide. If caught early, penile cancer is curable but men tend to ignore symptoms until the disease has advanced. Lance Pagliaro, M.D., professor in Genitourinary Medical Oncology at MD Anderson Cancer Center, discusses the basics, symptoms, diagnosis and treatment of penile cancer.

A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen

Testicular cancer basics

submitted by: mdanderson
Download from iTunes: https://itunes.apple.com/us/itunes-u/testicular-cancer-basics/id43184821... Testicular cancer is the most common malignant cancer in males between the ages of 15 and 34, but it could strike at any age. Symptoms are not always obvious and self-examination is not a recommended way to screen for testicular cancer. Lance Pagliaro, M.D., professor in Genitourinary Medical Oncology at MD Anderson Cancer Center, discusses the basics, symptoms, diagnosis and treatment of...

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

submitted by: enphpdom
Background: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season. Objective: The objective was to understand the seasonality of DNA methylation patterns in rural Gambian women. We studied natural...
Authors: P Dominguez-Salas, AM Prentice

Social Media Delivered Sexual Health Intervention: A Cluster Randomized Controlled Trial

submitted by: sheana
Design: Cluster randomized trial; data collected in 2010-2011; analyzed in 2011-2012 Setting/Participants: Individuals (seeds) recruited in multiple settings (online, via newspaper ads and face-to-face) who were asked to recruit up to three friends, who in turn recruited additional friends, extending three waves from the seed. Seeds and waves of friends were considered networks and exposed to either intervention or control condition. Intervention: Exposure to Just/Us, a Facebook page...
Authors: Sheana Bull, Deborah Levine, Sandra Black, Sarah Schmiege, John Santelli

Correcting for Inflammation Changes Estimates of Iron Deficiency among Rural Kenyan Preschool Children

submitted by: ebogrant5
The assessment of iron status where infections are common is complicated by the effects of inflammation on iron indicators and in this study we compared approaches that adjust for this influence. Blood was collected in 680 children (aged 6–35 mo) and indicators of iron status [(hemoglobin (Hb), zinc protoporphyrin (ZP), ferritin, transferrin receptor (TfR), and TfR/ferritin index)] and subclinical inflammation [(the acute phase proteins (APP) C-reactive protein (CRP), and a-1-acid...
Authors: Frederick Grant, Parminder Suchdev, Rafael Flores-Ayala, Conrad Cole, Usha Ramakrishnan, Laird Ruth, Reynaldo Martorell

Breast Cancer -- It Doesn't Just Strike Women

submitted by: mdanderson
There were about 1,970 new cases of invasive breast cancer diagnosed among men in the United States in 2010. Yet, because of the lack of awareness, diagnosis normally happens at a late stage. Breast cancer is branded a female disease, so males must brave the pink ribbons, women-only waiting rooms, etc. There are similarities and differences in male and female breast cancer. Sharon Giordano, M.D., associate professor and internist in the Department of Breast Medical Oncology at MD...

Renewed Sexual Pleasure for Couples Post-Prostate Cancer Treatment

submitted by: mdanderson
Download from iTunes: http://itunes.apple.com/us/itunes-u/renewed-sexual-pleasure-for/id431848... Erectile dysfunction is an adverse side effect for many prostate cancer patients that often causes unhappiness for the man's partner as well. Leslie Schover, Ph.D., professor in the Department of Behavioral Science at the University of Texas MD Anderson Cancer Center, has recently completed a clinical trial studying the effectiveness of counseling through face-to-face interaction versus...

Acute Ingestion of Long-Chain (n-3) Polyunsaturated Fatty Acids Decreases Fibrinolysis in Men with Metabolic Syndrome

submitted by: lrobinson
Individuals with metabolic syndrome (MetS) often have elevated plasma plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA), contributing to an increased risk of cardiovascular disease. PAI-1 and t-PA may be affected by chronic (n-3) long-chain PUFA [(n-3)LCPUFA] supplementation; however, the acute impact of fat ingestion on these risk factors has not been established. Our objective was to investigate the acute effect of (n-3)LCPUFA on plasma PAI-1, t-PA, and...
Authors: Camilla Montegaard, Hilary Tulk, Lotte Lauritzen, Tine Tholstrup, Lindsay e Robinson