Genetically Programmable Pathogen Sense and Destroy

submitted by: saurabh gupta

The video describes my invention of Engineered cells which can act as a live vaccine. These cells are programmed to intelligently detect a particular gut pathogen and then specifically and completely kill it without affecting the normal gut microbial flora. This automated approach thus prevents from horrible side effects of current antibiotics and growing resistance against them.

Good Day LA Interviews Dr. Bob Sears

submitted by: Sinupretforkids

Fox Morning News welcomes Pediatrician Doctor Bob Sears to discuss natural remedies. Renowned pediatrician Dr. Bob Sears has had excellent results with his patients using Bionorica's Sinupret for Kids.

Tuberculosis: A Persistent Threat to Global Health - Part 4: Targeting M. tuberculosis Carbon Metabolism In Vivo (26:12)

submitted by: video_collector
All pathogens must acquire and assimilate nutrients from their hosts in order to grow and multiply -- our tissues are literally their food -- yet surprisingly little is known about this fundamental aspect of the pathogenic lifestyle. Accumulating evidence suggests that M. tuberculosis might utilize fatty acids as its principal carbon and energy source during infection. The fourth part of this lecture describes work in our laboratory that is focused on identifying the metabolic pathways that...

Tuberculosis: A Persistent Threat to Global Health - Part 3: Phenotypic Heterogeneity and Antibiotic Tolerance (27:15)

submitted by: video_collector
The principal obstacle to successful treatment of tuberculosis is the lengthy duration of current regimens, which require administration of multiple drugs for 6-9 months. The requirement for prolonged therapy is attributed to sub-populations of bacillary "persisters" that are refractory to antimicrobials. The persisters are not drug-resistant in the conventional (heritable) sense and it is a mystery why they are spared whilst their genetically identical siblings are killed. The third part of...

Tuberculosis: A Persistent Threat to Global Health - Part 2: Tools for Tuberculosis Control: Not Just a Problem of Implementation (28:18)

submitted by: video_collector
Tuberculosis remains one of the most important causes of human disease and death despite the introduction of vaccination in 1921 and chemotherapy in 1952. Although these interventions are inexpensive and widely available their impact is limited. The effectiveness of vaccination is unclear; in clinical trials, the protection conferred by vaccination has been variable and generally poor. Although chemotherapy can be highly effective, multiple drugs must be administered for 6-9 months to...

Metabonomic profiling of the gut microbiome: Implications for human health James Kinross, Imperial College, London

submitted by: dougramsey
Microbial-mammalian metabolic cooperation is defined as the human ‘metabonome’. Transgenomic co-metabolic interactions within the metabonome greatly increase system complexity and this presents a significant challenge for elucidating the mechanisms by which the intestinal micro biome influences the host phenotype. By measuring and mathematically modelling changes in the levels of products of metabolism found in mammalian biological fluids and tissues, metabonomics offers fresh insight...

Diversity Profile of the Human Skin Microbiome in Health and Disease Elizabeth A. Grice, National Institutes of Health

submitted by: dougramsey

Elizabeth A. Grice of National Institutes of Health discusses "Diversity Profile of the Human Skin Microbiome in Health and Disease"

SDSU Geological Sciences Webinar - Stephen T. Hasiotis

submitted by: tcarrasc
Ichnology for the 21st Century: Understanding the differences between continental and marine trace fossils, with implications to the diversity, distribution, and evolution of soil biota ; Department of Geological Sciences, San Diego State University, Seminar Series ; The study of ichnology has come a long way since its inception and it continues to evolve. In particular, progress is being made in understanding the implications of trace fossils in the continental realm and how they can be...

Germ Proof Your Kids MWV26

submitted by: MicrobeWorld
Parents are often presented with conflicting messages about germs and cleanliness. On the one hand, the news headlines warn us about dangerous "superbugs." On the other hand, there is growing concern that over-cleaning and excessive hygiene may weaken children's immune systems. Fortunately, there is real, vetted science available to help us understand how to best protect, without overprotecting, our kids. In episode 26 of MicrobeWorld Video, we talk with Dr. Harley Rotbart, author of Germ...

Tuberculosis: A Persistent Threat to Global Health - Part 1: Tuberculosis: The Once and Future Plague (27:33)

submitted by: video_collector
Human population growth and urbanization have accelerated dramatically in recent centuries, providing unprecedented opportunities for microbes that use our bodies as vehicles for their own propagation and transmission. These conditions have led to the emergence of virulent new pathogens and the increased prevalence of "classic" scourges, such as Mycobacterium tuberculosis. This tenacious microbe is transmitted via infectious aerosols produced by individuals with pulmonary tuberculosis....