Intestinal microbiota and human health

submitted by: COMED2010
The central objective of the MetaHit project is to establish associations between the genes of the human intestinal microbiota and human health and disease. The research work is focused on two disorders of increasing importance in Europe, Inflamatory Bowel Disease (IBD) and obesity. First, we need to establish an extensive reference catalog of microbial genes and genomes present in the human intestine. The second challenge is to develop tools to determine which genes and genomes of the...

How to define human biological age

submitted by: COMED2010
Towards establishing biomarkers of human ageing “European Study to Establish Biomarkers of Human Ageing (MARK-AGE)” brings together 26 groups located in 14 European countries. The scientific background is the following: The rate of ageing in humans is not uniform, age-related changes in body function or composition that could serve as a measure of “biological” age and predict the onset of age-related diseases and/or residual lifetime are termed “biomarkers of ageing”. Within the...

Dogs help to decode human DNA

submitted by: COMED2010
Dogs are more than man’s best friends; they can help us unravelling the genetic of diseases such as cancer, epilepsy, cardiovascular troubles, diabetes etc. Living in the same environment human and dogs are suffering from the same diseases but the genetic complexity is quite lower in dogs. During 4 years 20 veterinary schools spread across Europe are working together to collect 10.000 blood samples from purebred dogs affected by similar diseases as human. The analysis of the genome of...

New heart valve development for children

submitted by: COMED2010
The general objective of the LifeValve project is to develop a new therapeutic strategy to treat heart valve disease. In particular, the development of a tissue engineered living heart valve, with the capacity of growth in accordance with the growths of children, which can be implanted without an operation by minimally invasive catheter technology will be addressed. The rationale for first focussing on paediatric applications is twofold: First, a novel, tissue engineered living heart valve...

Joint efforts in the fight against stroke

submitted by: COMED2010

The exploration of neurovascular dysfunction and the perfection of thrombolytic therapy in stroke are two core areas of research pursued by scientists of the European Stroke Network.

Novel antimalarial drug development

submitted by: COMED2010
The main objective of the AntiMal Integrated Project is to generate novel antimalarial drugs with potential for use in humans, specifically to progress candidate molecules to the “first time into humans” stage of drug development. To achieve this goal, leading groups of malaria researchers from Europe and Africa with expertise in malaria biology, chemotherapy and drug development have come together to exploit new scientific and political opportunities to secure the development of a...

Nasal vaccine against whooping cough

submitted by: COMED2010
Despite large coverage with efficacious vaccines, whooping cough is still a major cause of global childhood morbidity and mortality. In an effort to solve this problem, the Child-Innovac programme has developed a new vaccine designed to be given as a single dose at birth in order to protect young children, under 6 months of age, which is the most vulnerable age group and not sufficiently protected by the current vaccines. The new vaccine is based on a novel concept of nasal administration of...

European Research for diabetes patients

submitted by: COMED2010

The prevalences of obesity, Type 2 diabetes and the metablic syndrome are rising rapidly both in Europe and worldwide. There is evidence that this is due to the population taking less exercise and becoming more sedentary, coupled with the increased consumption of high fat, low fibre foods (fast food or convenience food). The EXGENESIS consortium aims to provide insights into the reasons why poor diet and lack of exercise contribute to increasing levels of obesity and diabetes.

A Firm Foundation For Private Data Analysis

submitted by: cdwork2003@yahoo.com
In the information realm, loss of privacy is usually associated with failure to control access to information, to control the flow of information, or to control the purposes for which information is employed. Differential privacy arose in a context in which ensuring privacy is a challenge even if all these control problems are solved: privacy-preserving statistical analysis of data. The problem of statistical disclosure control— revealing accurate statistics about a set of...
Authors: Cynthia Dwork

Introduction to Biomedical Ontologies #4: Ontology Term Enrichment Using RatMine

submitted by: jennifer.r.smith
You've done your experiments and you have a list of genes that might be of interest, but…what now? Or you keep seeing the term "ontology term enrichment analysis" in the papers you're reading and, well, you have a vague idea of what that means, but you aren't really sure. Whether you're interested in information about gene functions, diseases, phenotypes or pathways, this video provides an overview of what ontology term enrichment analysis is and how you can use the "widgets" in RatMine...