Trypanosoma cruzi in the chicken model. Autoimmune Chagas-like Heart Disease

submitted by: Antonio Teixeira
he administration of anti-trypanosome nitroderivatives curtails Trypanosoma cruzi infection in Chagas disease patients, but does not prevent destructive lesions in the heart. This observation suggests that an effective treatment for the disease requires understanding its pathogenesis. To understand the origin of clinical manifestations of the heart disease we used a chicken model system in which infection can be initiated in the egg, but parasite persistence is precluded. T. cruzi...
Authors: Teixeira Antonio rl, Gomes Clever, Nitz Nadjar, Alessandro sousa, Alves Roseneide, Sousa Alessandro, Cambraia Maria carolina, Cordeiro Ciro, Bernal Francisco m, Rosa Ana cassia, Hejnar Jiri, Leonardecz Eduardo, Hecht Mariana m

Bacillus thuringiensis Cry5B Protein Is Highly Efficacious as a Single-Dose Therapy against an Intestinal Roundworm Infection in

submitted by: raroian
Latest research from UCSD on new, powerful cure against intestinal parasitic roundworms (soil transmitted helminths) like hookworms, whipworms, and Ascaris. These parasites infect 2 billion of the poorest peoples and are a leading source of disease burden in school-aged children. The world has virtually ignored the issues of less than adequate drugs and emerging parasite resistance. Here we turn to an organic solution, natural soil bacterium Bacillus thuringiensis crystal protein (Cry5B)....

The New Anthelmintic Tribendimidine is an L-type (Levamisole and Pyrantel) Nicotinic Acetylcholine Receptor Agonist

submitted by: raroian
Background Intestinal parasitic nematodes such as hookworms, Ascaris lumbricoides, and Trichuris trichiura are amongst most prevalent tropical parasites in the world today. Although these parasites cause a tremendous disease burden, we have very few anthelmintic drugs with which to treat them. In the past three decades only one new anthelmintic, tribendimidine, has been developed and taken into human clinical trials. Studies show that tribendimidine is safe and has good clinical...
Authors: Yan Hu, Shu-Hua Xiao, Raffi V. Aroian