Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial

submitted by: efung
BACKGROUND: Patients with thalassemia major (Thal) frequently have low plasma zinc, which has been associated with low bone mass. OBJECTIVE: The objective was to determine the effect of zinc supplementation on bone mass in patients with Thal. DESIGN: Forty-two subjects (21 females aged 10-30 y) with Thal and low bone mass were randomly assigned to receive 25 mg Zn/d or placebo. Bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed by using dual-energy X-ray...
Authors: Ellen B. Fung, Janet L. Kwiatkowski, James N. Huang, Ginny Gildengorin, Janet C. King, Elliott P. Vichinsky

A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

submitted by: enphpdom
Background: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season. Objective: The objective was to understand the seasonality of DNA methylation patterns in rural Gambian women. We studied natural...
Authors: P Dominguez-Salas, AM Prentice

Social Media Delivered Sexual Health Intervention: A Cluster Randomized Controlled Trial

submitted by: sheana
Design: Cluster randomized trial; data collected in 2010-2011; analyzed in 2011-2012 Setting/Participants: Individuals (seeds) recruited in multiple settings (online, via newspaper ads and face-to-face) who were asked to recruit up to three friends, who in turn recruited additional friends, extending three waves from the seed. Seeds and waves of friends were considered networks and exposed to either intervention or control condition. Intervention: Exposure to Just/Us, a Facebook page...
Authors: Sheana Bull, Deborah Levine, Sandra Black, Sarah Schmiege, John Santelli

Correcting for Inflammation Changes Estimates of Iron Deficiency among Rural Kenyan Preschool Children

submitted by: ebogrant5
The assessment of iron status where infections are common is complicated by the effects of inflammation on iron indicators and in this study we compared approaches that adjust for this influence. Blood was collected in 680 children (aged 6–35 mo) and indicators of iron status [(hemoglobin (Hb), zinc protoporphyrin (ZP), ferritin, transferrin receptor (TfR), and TfR/ferritin index)] and subclinical inflammation [(the acute phase proteins (APP) C-reactive protein (CRP), and a-1-acid...
Authors: Frederick Grant, Parminder Suchdev, Rafael Flores-Ayala, Conrad Cole, Usha Ramakrishnan, Laird Ruth, Reynaldo Martorell

Renewed Sexual Pleasure for Couples Post-Prostate Cancer Treatment

submitted by: mdanderson
Download from iTunes: http://itunes.apple.com/us/itunes-u/renewed-sexual-pleasure-for/id431848... Erectile dysfunction is an adverse side effect for many prostate cancer patients that often causes unhappiness for the man's partner as well. Leslie Schover, Ph.D., professor in the Department of Behavioral Science at the University of Texas MD Anderson Cancer Center, has recently completed a clinical trial studying the effectiveness of counseling through face-to-face interaction versus...

Vulvar Cancer: Often Misdiagnosed as an Abscess

submitted by: mdanderson

Vulvar cancer is rare, with around 4,000 women in the United States diagnosed each year. Doctors often misdiagnose vulvar cancer as an abscess, but if caught early it is highly curable with little disfigurement or sexual dysfunction. Charles Levenback, M.D., and Anuja Jhingran, M.D., both professors in the Department of Gynecologic Oncology at the University of Texas MD Anderson Cancer Center, discuss the basics, diagnoses and treatment of vulvar cancer.

Vaginal Cancer Linked to Human Papillomavirus Virus (HPV)

submitted by: mdanderson

Vaginal cancer is rare, with 2,000 new cases diagnosed in the United States each year. Along with cervix and vulvar cancers, the most common cause of vaginal cancer is the Human Papillomavirus Virus (HPV). Charles Levenback, M.D., and Anuja Jhingran, M.D., both professors in the Department of Gynecologic Oncology at the University of Texas MD Anderson Cancer Center, discuss the basics, diagnoses, and treatment for vaginal cancer.

By Carter

submitted by: bccdc
The division of STI/HIV Prevention and Control collaborated with the Public Health Agency of Canada on a research study aimed at exploring issues in the life of street youth that contribute to the risk of contracting sexually transmitted infections including AIDS. Once the study was over, the research team engaged the youth to develop video clips that help tell the youth’s stories around sexual risk while living on the street and some of the research findings. The script and artwork were...

Fertility Preservation

submitted by: mcgheekkm

Dr. Jani Jensen, Assistant Professor in the Department of Reproduction Endocrinology and Fertility at Mayo Clinic in Rochester, MN, discusses her article on fertility preservation, (Available at: http://tinyurl.com/38s6eqa ) which appears in the January 2011 issue of Mayo Clinic Proceedings.