SSPPS205 2012 Informatics in Drug Discovery

submitted by: Phil

Presented by Philip Bourne as part of a P1 PharmD course in Pharmacy Informatics at UCSD.

BindingDB: Download all data for a target of interest

submitted by: gnicpro

This tutorial describes how to retrieve all published binding data for a particular protein target of interest in BindingDB.
http://bindingdb.org

BindingDB: Find and view all data for a target of interest

submitted by: gnicpro

This tutorial describes how to view all published binding data for a protein target in BindingDB
http://bindingdb.org

UCSD Phar201 Computational Systems Medicine

submitted by: Phil

This is a podcast and slides of a lecture given on Nov 23, 2011 in the course Phar201 (http://www.sdsc.edu/pb/edu/pharm201/) at the University of California San Diego by graduate student Roger Chang. It covers the interface between structural bioinformatics and systems biology form the viewpoint of off-target drug effects and large scale metabolic modeling.

UCSD Phar201 Protein Ligand Interactions

submitted by: Phil

This is a podcast and slides of a lecture given on Nov 02, 2011 in the course Phar201 (http://www.sdsc.edu/pb/edu/pharm201/) at the University of California San Diego by Prof. Phil Bourne. It covers some aspects of protein ligand interactions with emphasis on SMAP for determining similar ligand binding sites and the pharmacological implications.

UCSD Phar201 Chemical Data and Computer-Aided Drug Discovery

submitted by: Phil

This is a podcast and slides of a lecture given on Nov 9, 2011 in the course Phar201 (http://www.sdsc.edu/pb/edu/pharm201/) at the University of California San Diego by Prof. Michael Gilson. It covers structure and ligand based structure methods used in drug discovery.

Epizyme - HMT "Tree" Presentation Video

submitted by: Epizyme
A survey of the human genome was performed to understand the constituency of protein methyltransferases (both protein arginine and lysine methyltransferases) and the relatedness of their catalytic domains. We identified 51 protein lysine methyltransferase proteins based on similarity to the canonical Drosophila Su(var)3-9, enhancer of zeste (E(z)), and trithorax (trx) domain. Disruptor of telomeric silencing-1-like, a known protein lysine methyltransferase, did not fit within the protein...
Authors: Christopher Sneeringer, Margaret Scott, Keith Elliston, Danielle Johnston, Lei Jin, L. fred Jerva, Victoria Richon, Robert Copeland, Christina Majer

Michael A. Kron, M.D., M.S.

submitted by: MCW_BBC

Michael A. Kron, M.D., M.S., a professor of Medicine and the Biotechnology and Bioengineering Center at the Medical College of Wisconsin, describes his research on drug discovery with filariasis and infectious disease.

What is the Biotechnology and Bioengineering Center at the Medical College of Wisconsin

submitted by: MCW_BBC

Andrew Greene, Ph.D., describes the research foci of the Biotechnology and Bioengineering Center at the Medical College of Wisconsin in Milwaukee, WI.

Network Pharmacology - Bio-IT World 2010 Interview with Philip E. Bourne

submitted by: Phil
The notion of one-drug binding to one receptor to treat one disease is a dated concept. Using new bioinformatics and cheminfomatics techniques combined with systems biology we are at the beginning of an era when we can better predict the impact of a drug on the complete system. In principle this could lead to more and better drugs. This interview outlines some of these concepts which are to be discussed at the forthcoming Bio-IT Conference in Boston, USA see...