Research aims to capture, interrogate single cancer cells

submitted by: mdanderson
http://www.mdanderson.org/newsroom/news-releases/2012/project-to-capture... Nicholas Navin, Ph.D., of MD Anderson's Genetics Department, has a plan to sort out the genetic differences among individual tumor cells at different stages of cancer development, then analyze and compare their active mutations. The results should track the evolution of triple-negative breast cancer from initial tumor, to circulating tumor cell to metastatic cell. This new approach, funded by the Damon Runyon...

Male breast cancer: patient and doctor discuss experience and treatment

submitted by: mdanderson

Male breast cancer accounts for approximately one percent of all breast cancer cases diagnosed in the United States each year. Listen to male breast cancer patient, Oliver Bogler, Ph.D.and his MD Anderson Cancer Center oncologist, Sharon Giordano, M.D., talk about male breast cancer, including the research, treatment, and Bogler’s experience as a “man in pink.”

African American women less likely to receive improved surgical procedure for breast cancer

submitted by: mdanderson
African American women with early stage, invasive breast cancer were 13 percent less likely than Caucasian women with the same diagnosis to receive a minimally invasive technique, axillary sentinel lymph node (SLN) biopsy, years after the procedure had become the standard of surgical care, according to research from MD Anderson Cancer Center. The older technique, axillary lymph node dissection (ALND), is associated with a higher rate of lymphedema and worse outcome. Dalliah Black, M.D.,...

Circulating tumor cells may predict prognosis in early breast cancer

submitted by: mdanderson
A study published in the June Lancet Oncology reports early stage breast cancer patients who produce circulating tumor cells (CTC) may be at greater risk for breast cancer recurrence. Until now, lymph node biopsy has been the best predictor of prognosis. More research is needed to learn how to apply this new discovery, but the study is a step forward in understanding what is happening biologically. Anthony Lucci, M.D., professor, and Isabelle Bedrosian, M.D., associate professor, both in...

Science Nation - Body Rhythms and Breast Cancer

submitted by: nsf
Could working the night shift alter a woman's body clock enough to cause breast cancer? "One minute you're a healthy person, the next minute you have breast cancer." Ettamay (last name withheld) is up early these days. She lives a much different life than she did when she was a nurse working the night shifts. She would be just getting to sleep at this early morning hour. "I was always exhausted," she says. "I don't know any of the nurses, especially the night shift gals, that weren't...

Whole Blueberry Powder Modulates the Growth and Metastasis of MDA-MB-231 Triple Negative Breast Tumors in Nude Mice

submitted by: Stedda68
Previous studies in our laboratory demonstrated that blueberry (BB) extract exhibited antitumor activity againstMDA-MB-231 triple negative breast cancer (TNBC) cells and decreased metastatic potential in vitro. The current study tested 2 doses of whole BB powder, 5 and 10% (wt:wt) in the diet, against MDA-MB-231 tumor growth in female nude mice. In this study, tumor volume was 75%lower in mice fed the 5%BB diet and 60% lower in mice fed the 10%BB diet than in control mice (P # 0.05)....
Authors: Lynn Adams, Noriko Kanaya, Sheryl Phung, Zheng Liu, Shiuan Chen

Unsung Hero: Maritza Valero

submitted by: mdanderson

Meet Maritza Valero. She began her journey at MD Anderson six years ago. With a degree in dentistry, Maritza's six-month volunteer position unexpectedly redirected her career path. She's now a supervisor in the Appearances shop in Mays Clinic. Appearances offers breast forms, bras and other specialty items for cancer patients

Making Sense of Hormone Replacement Therapy & Breast Cancer Risk

submitted by: mdanderson
Jennifer Litton M.D. makes sense of hormone replacement therapy and its relationship to your risk of getting breast cancer. Please visit: www.mdanderson.org/prevention for more information regarding prevention and screening. Dr. Jennifer Litton, Assistant Professor of Breast Medical Oncology, at The University of Texas MD Anderson Cancer Center discusses hormone replacement therapy and breast cancer risk. View other videos at www.mdanderson.org/videos

Breast Cancer Coalition talk on Open Notebook Science

submitted by: jcbradley
Jean-Claude Bradley presents "Accelerating Discovery by Sharing: a case for Open Notebook Science" on May 1, 2011 at the National Breast Cancer Coalition Annual Advocacy Conference in Arlington, VA. First a few examples are provided which show how a lack of transparency in science can retard progress by creating ambiguity. Demonstrations of the use of Open Notebook Science in malaria research, solubility and other chemistry related applications then follow. Examples of web services...

Identification and Regulation of c-Myb Target Genes in MCF-7 cells.

submitted by: aquintan
BACKGROUND: The c-Myb transcription factor regulates differentiation and proliferation in hematopoietic cells, stem cells and epithelial cells. Although oncogenic versions of c-Myb were first associated with leukemias, over expression or rearrangement of the c-myb gene is common in several types of solid tumors, including breast cancers. Expression of the c-myb gene in human breast cancer cells is dependent on estrogen stimulation, but little is known about the activities of the c-Myb...
Authors: Anita m. Quintana, Fan Liu, John p. O'rourke, Scott a. Ness