Eddy Rubin at the 2014 DOE JGI Genomics of Energy & Environment Meeting

submitted by: JGI
Eddy Rubin, DOE JGI Director, at the 9th Annual Genomics of Energy & Environment Meeting on March 19, 2014 in Walnut Creek, Calif. The talk is related to a study published in the journal Science - details at http://jgi.doe.gov/glimpse-natures-looking-glass-to-find-the-genetic-cod... .

Dietary actinidin from kiwifruit (Actinidia deliciosa cv. Hayward) increases gastric digestion and the gastric emptying rate of several dietary proteins in growing rats

submitted by: cmontoya
Dietary actinidin influences the extent to which some dietary proteins are digested in the stomach, and it is hypothesized that the latter modulation will in turn affect their gastric emptying rate (GE). In this study, the effect of dietary actinidin on GE and gastric digestion of 6 dietary protein sources was determined in growing rats. Each dietary protein source [beef muscle, gelatin, gluten, soy protein isolate (SPI), whey protein isolate, and zein] was included in 2 semisynthetic diets...
Authors: Carlos A. Montoya, Jason P. Hindmarsh, Lucrecia Gonzalez, Mike J. Boland, Paul J. Moughan, Shane M. Rutherfurd

Supplementing a low protein diet with dibasic amino acids increases urinary calcium excretion in young women

submitted by: jld03009
Increasing dietary protein within a physiologic range stimulates intestinal calcium absorption, but it is not known if specific amino acids or dietary protein as a whole are responsible for this effect. Therefore, we selectively supplemented a lowprotein (0.7 g/kg) diet with either the calcium-sensing receptor-activating amino acids (CaSR-AAAs) L-tryptophan, L-phenylalanine, and L-histidine, or the dibasic amino acids (DAAs) L-arginine and L-lysine, to achieve intakes comparable to the...
Authors: Jessica Bihuniak, Rebecca Sullivan, Christine Simpson, Donna Caseria, Tania Huedo-Medina, Kimberly O’Brien, Jane Kerstetter, Karl Insogna

Silencing the Menkes Copper-Transporting ATPase (Atp7a) Gene in Rat Intestinal Epithelial (IEC-6) Cells Increases Iron Flux via Transcriptional Induction of Ferroportin 1 (Fpn1)

submitted by: jfcollins
The Menkes copper-transporting ATPase (Atp7a) gene is induced in rat duodenum during iron deficiency, consistent with copper accumulation in the intestinal mucosa and liver. To test the hypothesis that ATP7A influences intestinal iron metabolism, the Atp7a gene was silenced in rat intestinal epithelial (IEC-6) cells using short hairpin RNA (shRNA) technology. Perturbations in intracellular copper homeostasis were noted in knockdown cells, consistent with the dual roles of ATP7A in pumping...
Authors: Sukru Gulec, James F. Collins

20131029 - Protein Prediction 2 - Tobias Hamp - Homology Based Prediction of Protein Function

submitted by: rostlab

Date: 20131029

Course: Protein Prediction 2

Title: Homology Based Prediction of Protein Function

Speaker: Tobias Hamp

Audience: Computer Science students

20131024 - Protein Prediction 2 - Burkhard Rost - Introduction to protein function

submitted by: rostlab

Date: 20131024

Course: Protein Prediction 2

Title: Introduction to protein function

Speaker: Burkhard Rost

Audience: Computer Science students