User Profile


Leo Chalupa
Research Interests:
Development and plasticity of the mammalian visual system. Factors that regulate the establishment of functional, neurochemical, and structural properties of retinal ganglion cells.
Center for Neuroscience
About Leo:
I am a co-founder of SciVee and a Professor of Ophthalmology and Neurobiology at the University of California, Davis.
Chalupa, L. M. and Huberman, A. D. A new perspective on the role of activity in the development of eye-specific retinogeniculate projections. The Cognitive Neurosciences Third Edition, Ed: M.S. Gazzaniga, MIT Press, Cambridge Mass, 2004, in press.

Chalupa, L. M. and Werner J. S. (Editors) The Visual Neurosciences, 2004, MIT Press, Cambridge, Mass. Volumes 1 and 2, 1694 pages.

Chalupa, L. M. and Gunhan, E. Development of On and Off retinal pathways and retinogeniculate projections. Progress in Retinal and Eye Research, 2004, 23: 31-51.

Günhan, E., Van der List, D. and Chalupa, L. M. Ectopic photoreceptors and cone bipolar cells in the developing and mature retina. Journal of Neuroscience 2003, 23: 1383-1389.

Chalupa, L. M. Development of the visual system. In: Encyclopedia of Neuroscience, Ed: G. Adelman, Elsevier Science, Amsterdam, 2003.

Huberman, A., Wang G-Y, Liets, L. C., Collins, O. A., Chapman, B. and Chalupa, L. M. Eye-specific retinogeniculate segregation independent of normal neuronal activity. Science 2003, 300: 994-998.

Wang, G-Y, Liets, L. C. and Chalupa, L. M., Nitric oxide differentially modulates On and Off responses of retinal ganglion cells. Journal of Neurophysiology 2003, 90: 1304-1313.

Liets, L. C., Olshausen, B. A., Wang, G-Y and Chalupa, L. M. Spontaneous activity of morphologically identified ganglion cells in the developing ferret retina. Journal of Neuroscience 2003, 23:7343-7350.

Chalupa, L. M. and J.S. Werner (Editors). 2003. The Visual Neurosciences, MIT Press, in press.

Günhan, E., D. van der List, and L.M. Chalupa. 2002. Ectopic photoreceptors and cone bipolar cells in the developing and mature retina. J. Neuroscience, in press.

Günhan, E., P.V. Choudary, T.E. Landerholm, and L.M. Chalupa. 2002. Depletion of cholinergic amacrine cells by a novel immunotoxin does not perturb the formation of segregated On and Off cone bipolar cell projections. J. Neuroscience, 22: 2265-2273.

Wang, G-Y, L.C. Liets, and L.M. Chalupa. 2001. Unique functional properties of On and Off pathways in the developing mammalian retina. J. Neuroscience, 21:4310-4317.

Gunhan-Agar, E., D. Kahn, and L.M. Chalupa. 2000. Segregation of On and Off bipolar cell axonal arbors in the absence of retinal ganglion cells. J. Neuroscience, 2000, 20, 308-314.

Cook, J. and L.M. Chalupa. 2000. Retinal mosaics: new insights on an old concept. Trends in Neuroscience, 23, 26-34.

Snider, C.J., C. Dehay, H. Kennedy, M. Berland and L.M. Chalupa. 1999. Formation of ey-specific projections in the fetal monkey reflects the loss of retinal fibers rather than the restructuring of axonal processes. J. Neuroscience, 19(1).

Bisti, S., C. Gargini and L.M. Chalupa. 1998. Blockade of glutamate-mediated activity in the developing retina perturbs functional segregation of ON and OFF pathways. J. Neuroscience 18:5019-5025.

Chalupa, L.M. and B.L. Finlay (Eds.). 1998. Development and Organization of the Retina: From Molecules to Function, Plenum Press, New York.

Chalupa, L.M. and C.J. Snider. 1998. Topographic specificity in the retinocollicular projection of the developing ferret: An anterograde tracing study. Journal of Comparative Neurology, 392:35-47.

Wang, G.Y., D.W. Robinson and L.M. Chalupa. 1998. Calcium-activated potassium conductances in retinal ganglion cells of the ferret. Journal of Neurophysiology, 151-158.

Wang, G.Y., G.-M. Ratto, S. Bisti and L.M. Chalupa. 1997. Functional development of intrinsic properties in ganglion cells of the mammalian retina. Journal of Neurophysiology, 2895-2903.

Meissirel, C., K.C. Wikler, L.M. Chalupa and P. Rakic. 1997. Early divergence of functional subsystems in the embryonic primate visual system. Proceedings of the National Academy of Science USA 94:5900-5905.

Robinson, D.W. and L.M. Chalupa. 1997. Intrinsic temporal properties of retinal ganglion cells: a comparison of alpha and beta cells. Current Biology 7:366-374.

Chalupa, L.M., C.J. Snider and M. Kirby. 1996. Topographic organization in the retinocollicular pathway of the fetal cat demonstrated by retrograde labeling of ganglion cells. Journal of Comparative Neurology 368:295-303.

Chalupa, L.M., C. Meissirel and B. Lia. 1996. Specificity of retinal ganglion cell projections in the embryonic rhesus monkey. Perspective of Developmental Neurobiology 3:223-231.

Bodnarenko, S.R., G. Jeyarasasingam and L. M. Chalupa. 1995. Development and regulation of dendritic stratification in retinal ganglion cells by glutamate-mediated afferent activity. Journal of Neuroscience 15:7037-7045.

Hutsler, J.J. and L.M. Chalupa. 1995. The development of neuropeptide Y immunoreactive amacrine and ganglion cells in the pre- and postnatal cat retinal. Journal of Comparative Neurology 361:152-164.

Skaliora, I., D.W. Robinson, R.P. Scobey and L.M. Chalupa. 1995. Properties of K+ conductances in cat retinal ganglion cells during the period of activity-mediated refinements in retinofugal pathways. European Journal of Neuroscience 7:1558-1568.

Miguel-Hidalgo, J.J., K.J. Angelides and L.M. Chalupa. 1995. Distinct temporal patterns of expression of sodium channel-like immunoreactivity during the prenatal development of the monkey and cat retina. European Journal of Neuroscience 7:535-546.

Chalupa, L. M. 1995. The nature /nurture of retinal ganglion cell development. The Cognitive Neurosciences a Handbook for the Field. Ed. M. S. Gazzaniga, MIT Press, 37-50.

Hutsler, J.J. and L.M. Chalupa. 1994. Neuropeptide Y immunoreactivity identifies a regularly arrayed group of amacrine cells within the cat retina. Journal of Comparative Neurology 346:481-489.

Meissirel, C. and L.M. Chalupa. 1994. Organization of pioneer retinal axons within the optic tract of the rhesus monkey. Proceedings of the National Academy of Science USA 91:3906-3910.

Miguel-Hidalgo, J.J., C.J. Snider, K.J. Angelides and L. M. Chalupa. 1994. Voltage-dependent sodium channel alpha subunit immunoreactivity is expressed by distinct cell types of cat and monkey retina. Visual Neuroscience 11:219-228.

Hutsler, J.J., C.A. White and L.M. Chalupa. 1993. Neuropeptide Y immunoreactivity identifies a group of gamma-type retinal ganglion cells in the cat. Journal of Comparative Neurology 346:481-489.

Skaliora, I., R.P. Scobey and L.M. Chalupa. 1993. Prenatal development of excitability in cat retinal ganglion cells: Action potentials and sodium currents. Journal of Neuroscience 13, 313-323.

Chalulpa, L.M., I. Skaliora and R.P. Scobey. 1993. Responses of isolated cat retinal ganglion cells to injected currents during development. Progress in Brain Research: The Visually Responsive Neuron- From Basic Neurophysiology to Behavior (S. Molotchnikoff and T. P. Hicks, Eds) Elsvier Science Publishers 95:25-31.
History of Education and Employment
Distinguished Professor of Ophthalmology and Neurobiology
Chair, Section of Neurobiology, Physiology, and Behavior