Daniel Bozinov on "Challenges in Genomic Cloud Computing" at the 2012 Sequencing, Finishing, Analysis in the Future Meeting held June 5-7, 2012 in Santa Fe, New Mexico.

For a number of cancersubtypes it is crucial to determine if a mutation is present in genes like KRAS, EGFR, BRAF and PIK3CA. The testresults will be consequently used to predict the response to therapy. We demonstrate the workflow of this process in the Molecular Tumour Diagnostics group in the department of Pathology at the Leiden University Medical Center in the Netherlands. For more information: LUMC Pathology SLMP.nl (Dutch only) Citation: Rapid KRAS, EGFR, BRAF and PIK3CA...

There were about 1,970 new cases of invasive breast cancer diagnosed among men in the United States in 2010. Yet, because of the lack of awareness, diagnosis normally happens at a late stage. Breast cancer is branded a female disease, so males must brave the pink ribbons, women-only waiting rooms, etc. There are similarities and differences in male and female breast cancer. Sharon Giordano, M.D., associate professor and internist in the Department of Breast Medical Oncology at MD...

Wnt/?-catenin signaling plays important roles in many developmental processes including neural crest-derived melanocyte development and migration. However, the effective contribution of Wnt/?-catenin pathway in melanogenesis in adult human melanocytes has not been fully elucidated. Here, we report that in melanoma cells and in normal human melanocytes melanogenesis stimulation by ?-MSH induces phosphorylation of ?-catenin-Ser675 and stabilization of ?-catenin protein. Activation of PKA by...

Dr. Jani Jensen, Assistant Professor in the Department of Reproduction Endocrinology and Fertility at Mayo Clinic in Rochester, MN, discusses her article on fertility preservation, (Available at: http://tinyurl.com/38s6eqa ) which appears in the January 2011 issue of Mayo Clinic Proceedings.

Dr. Manish Kohli of Mayo Clinic discusses his January 2010 Mayo Clinic Proceedings article (http://tinyurl.com/yk2avz4) on new developments in the medical management of prostate cancer.

Dr. Shaji K Kumar, Associate Professor of Hematology and Medicine at Mayo Clinic in Rochester, MN, discusses updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines (direct link available at http://tiny.cc/V2dk9 or visit journal at www.mayoclinicproceedings.com ). The identification of well-defined and reproducible prognostic factors and introduction of new therapies with unique modes of action and impact on disease outcome have for the first time...

Dr. S. Vincent Rajkumar, Mayo Clinic hematologist, discusses the first systematic study (published in August issue of Mayo Clinic Proceedings available at http://tinyurl.com/lr55lc) to determine association of Monoclonal Gammopathy of Undetermined Significance (MGUS) with all diseases in 17,398 patients.