DNA Repair RNAi Screen Identifies SPG48

submitted by: biomiko

A Genome-Scale DNA Repair RNAi Screen Identifies SPG48 as a Novel Gene Associated with Hereditary Spastic Paraplegia

http://www.plosbiology.org/article/info%3Adoi%2F10.1371%2Fjournal.pbio.1...

Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition

submitted by: scivee-team

Atanu Maiti shares his poster presentation at the Experimental Biology 2008 conference.

The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers

submitted by: BernardFriedenson
Background The present study was designed to test the hypothesis that inactivation of virtually any component within the pathway containing the BRCA1 and BRCA2 proteins would increase the risks for lymphomas and leukemias. In people who do not have BRCA1 or BRCA2 gene mutations, the encoded proteins prevent breast/ovarian cancer. However BRCA1 and BRCA2 proteins have multiple functions including participating in a pathway that mediates repair of DNA double strand breaks by error-free...
Authors: Bernard Friedenson