Zinc supplementation improves bone density in patients with thalassemia: a double-blind, randomized, placebo-controlled trial

submitted by: efung
BACKGROUND: Patients with thalassemia major (Thal) frequently have low plasma zinc, which has been associated with low bone mass. OBJECTIVE: The objective was to determine the effect of zinc supplementation on bone mass in patients with Thal. DESIGN: Forty-two subjects (21 females aged 10-30 y) with Thal and low bone mass were randomly assigned to receive 25 mg Zn/d or placebo. Bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed by using dual-energy X-ray...
Authors: Ellen B. Fung, Janet L. Kwiatkowski, James N. Huang, Ginny Gildengorin, Janet C. King, Elliott P. Vichinsky

A diet rich in high glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles through modulating mitochondrial function

submitted by: Andrew Chapple
Background: Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD). Objective: We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas. Design: Subjects were randomly assigned to consume 400 g...
Authors: Charlotte Armah, Maria Traka, Jack Dainty, Marianne Defernez, Astrid Janssens, Wing Leung, John Potter, Richard Mithen

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women

submitted by: enphpdom
Background: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were exposed to famine or who conceived in the Gambian rainy season. Objective: The objective was to understand the seasonality of DNA methylation patterns in rural Gambian women. We studied natural...
Authors: P Dominguez-Salas, AM Prentice

Social Media Delivered Sexual Health Intervention: A Cluster Randomized Controlled Trial

submitted by: sheana
Design: Cluster randomized trial; data collected in 2010-2011; analyzed in 2011-2012 Setting/Participants: Individuals (seeds) recruited in multiple settings (online, via newspaper ads and face-to-face) who were asked to recruit up to three friends, who in turn recruited additional friends, extending three waves from the seed. Seeds and waves of friends were considered networks and exposed to either intervention or control condition. Intervention: Exposure to Just/Us, a Facebook page...
Authors: Sheana Bull, Deborah Levine, Sandra Black, Sarah Schmiege, John Santelli

Bone Cancer Surgery Options for the Adult Patient

submitted by: mdanderson
Valerae Lewis, M.D., Associate Professor in The University of Texas MD Anderson Cancer Center Department of Orthopaedic Oncology, discusses the many surgery options for bone cancer patients. Limb salvage surgery replaces the cancerous bone with either a bone graft from another person (allowgraft), a metal implant or a combination of the two (allo-prosthetic). After amputation of the lower leg, rotationplasty moves the ankle joint to where the knee once was to function as the knee joint. MD...

Correcting for Inflammation Changes Estimates of Iron Deficiency among Rural Kenyan Preschool Children

submitted by: ebogrant5
The assessment of iron status where infections are common is complicated by the effects of inflammation on iron indicators and in this study we compared approaches that adjust for this influence. Blood was collected in 680 children (aged 6–35 mo) and indicators of iron status [(hemoglobin (Hb), zinc protoporphyrin (ZP), ferritin, transferrin receptor (TfR), and TfR/ferritin index)] and subclinical inflammation [(the acute phase proteins (APP) C-reactive protein (CRP), and a-1-acid...
Authors: Frederick Grant, Parminder Suchdev, Rafael Flores-Ayala, Conrad Cole, Usha Ramakrishnan, Laird Ruth, Reynaldo Martorell

Food Insufficiency Is Associated with High-Risk Sexual Behavior among Women in Botswana and Swaziland

submitted by: jeveleth
Background Both food insufficiency and HIV infection are major public health problems in sub-Saharan Africa, yet the impact of food insufficiency on HIV risk behavior has not been systematically investigated. We tested the hypothesis that food insufficiency is associated with HIV transmission behavior. Methods and Findings We studied the association between food insufficiency (not having enough food to eat over the previous 12 months) and inconsistent...
Authors: Sheri d Weiser, Karen Leiter, David r Bangsberg, Lisa m Butler, Fiona percy-de Korte, Zakhe Hlanze, Nthabiseng Phaladze, Vincent Iacopino, Michele Heisler