Dr. Philip R. Greipp, MD, Mayo Clinic, discusses his article entitled “Idiopathic Systemic Capillary Leak Syndrome (Clarkson’s Disease): the Mayo Clinic Experience” (available at: http://tinyurl.com/24gyvd7 ), published Online First at Mayo Clinic Proceedings. This retrospective study describes clinical features, natural history, and outcome in a cohort of 25 consecutive patients with systemic capillary leak syndrome.