Methylphenidate Decreased the Amount of Glucose Needed by the Brain to Perform a Cognitive Task

May 22, 2008

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The use of stimulants (methylphenidate and amphetamine) as cognitive enhancers by the general public is increasing and is controversial. It is... » More
PLoS ONE. 2008 Apr 16; 3(4):e2017
Nora d. Volkow, Joanna s. Fowler, Gene-jack Wang, Frank Telang, Jean Logan, Christopher Wong, Jim Ma, Kith Pradhan, Helene Benveniste, James m. Swanson

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  1. Conners CK (2002) Forty years of methylphenidate treatment in Attention-Deficit/Hyperactivity Disorder.. J Atten Disord 6: S17-S30.
  2. Elliott R, Sahakain BJ, Matthews K, Bannerjea A, Rimmer J (1997) Effects of methylphenidate on spatial working memory and planning in healthy young adults.. Psychopharmacology (Berl) 131: 196-206.
  3. Sahakian B, Morein-Zamir S (2007) Professor's little helper.. Nature 450: 1157.
  4. Volkow ND, Swanson JM (2008) The action of enhancers can lead to addiction.. Nature 451: 520.
  5. Kuczenski R, Segal DS (1997) Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: comparison with amphetamine.. J Neurochem 68: 2032-2037.
  6. Kiyatkin EA, Rebec GV (1996) Dopaminergic modulation of glutamate-induced excitations of neurons in the neostriatum and nucleus accumbens of awake, unrestrained rats.. J Neurophysiol 75: 142-153.
  7. Hirata A, Aguilar J, Castro-Alamancos MA (2006) Noradrenergic activation amplifies bottom-up and top-down signal-to-noise ratios in sensory thalamus.. J Neurosci 26: 4426-4436.
  8. Fan J, McCandliss B, Fossella J, Flombaum J, Posner M (2005) The activation of attentional networks.. Neuroimage 26: 471-479.
  9. Mehta MA, Owen AM, Sahakian BJ, Mavaddat N, Pickard JD (2000) Methylphenidate enhances working memory by modulating discrete frontal and parietal lobe regions in the human brain.. J Neurosci 20(6): RC65.
  10. Schweitzer JB, Lee DO, Hanford RB, Zink CF, Ely TD (2004) Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder: normalization of behavior but not related brain activity.. Biol Psychiatry 56: 597-606.
  11. Gjedde A, Marrett S, Vafaee M (2002) Oxidative and nonoxidative metabolism of excited neurons and astrocytes.. J Cereb Blood Flow Metab 22: 1-14.
  12. Fox PT, Raichle ME (1986) Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.. Proc Natl Acad Sci U S A 83: 1140-1144.
  13. Ginsberg MD, Chang JY, Kelley RE, Yoshii F, Barker WW (1988) Increases in both cerebral glucose utilization and blood flow during execution of a somatosensory task.. Annals of Neurology 23: 152-160.
  14. Keeler JD, Pichler EE, Ross J (1989) Noise in neural networks: thresholds, hysteresis, and neuromodulation of signal-to-noise.. Proc Natl Acad Sci U S A 86: 1712-1716.
  15. Kiyatkin EA (2002) Dopamine in the nucleus accumbens: cellular actions, drug- and behavior-associated fluctuations, and a possible role in an organism's adaptive activity.. Behav Brain Res 137: 27-46.
  16. Seamans JK, Yang CR (2004) The principal features and mechanisms of dopamine modulation in the prefrontal cortex.. Prog Neurobiol 74: 1-58.
  17. Rolls ET, Thorpe SJ, Boytim M, Szabo I, Perrett DI (1984) Responses of striatal neurons in the behaving monkey. 3. Effects of iontophoretically applied dopamine on normal responsiveness.. Neuroscience 12: 1201-1212.
  18. Woodward DJ, Moises HC, Waterhouse BD, Hoffer BJ, Freeman R (1979) Modulatory actions of norepinephrine in the central nervous system.. Fed Proc Fed Am Soc Exp Biol 38: 2109-2115.
  19. Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van Essen DC, Raichle ME (2005) The human brain is intrinsically organized into dynamic, anticorrelated functional networks.. Proc Natl Acad Sci U S A 102: 9673-9678.
  20. Conners CK (1966) The effect of dexedrine on rapid discrimination and motor control of hyperkinetic children under mil.d stress.. J Nervous Mental Disease 142: 429-433.
  21. Porrino LJ, Rapoport JL, Behar D, Ismond DR, Bunney WE (1983) A naturalistic assessment of the motor activity of hyperactive boys. II. Stimulant drug effects.. Arch Gen Psychiatry 40: 688-693.
  22. Weber K (1985) Methylphenidate: rate-dependent drug effects in hyperactive boys.. Psychopharmacology (Berl) 85: 231-235.
  23. Teicher MH, Polcari A, Anderson CM, Andersen SL, Lowen SB (2003) Rate dependency revisited: understanding the effects of methylphenidate in children with attention deficit hyperactivity disorder.. J Child Adolesc Psychopharmacol 13: 41-51.
  24. Gusnard DA, Raichle ME (2001) Searching for a baseline: functional imaging and the resting human brain.. Nat Rev Neurosci 2: 685-694.
  25. Mason MF, Norton MI, Van Horn JD, Wegner DM, Grafton ST (2007) Wandering minds: the default network and stimulus-independent thought.. Science 315: 393-395.
  26. Rapoport JL, Inoff-Germain G (2002) Responses to methylphenidate in Attention-Deficit/Hyperactivity Disorder and normal children: update 2002.. J Atten Disord 6: S57-S60.
  27. Mattay VS, Callicott JH, Bertolino A, Heaton I, Frank JA (2000) Effects of dextroamphetamine on cognitive performance and cortical activation.. Neuroimage 12: 268-275.
  28. Volkow ND, Wang GJ, Fowler JS, Telang F, Maynard L (2004) Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain.. Am J Psychiatry 161: 1173-1180.
  29. Matochik JA, Liebenauer LL, King AC, Szymanski HV, Cohen RM (1994) Cerebral glucose metabolism in adults with attention deficit hyperactivity disorder after chronic stimulant treatment.. Amer J Psychiatry 151: 658-664.
  30. Wang GJ, Volkow ND, Roque CT, Cestaro VL, Hitzemann RJ (1993) Functional importance of ventricular enlargement and cortical atrophy in healthy subjects and alcoholics as assessed with PET, MR imaging, and neuropsychologic testing.. Radiology 186: 59-65.
  31. Srinivas NR, Hubbard JW, Quinn D, Korchinski ED, Midha KK (1991) Extensive and enantioselective presystemic metabolism of dl-threo-methylphenidate in humans.. Prog Neuropsychopharmacol Biol Psychiatry 15: 213-220.
  32. Friston KJ, Holmes AP, Worsley KJ, Poline JP, Frith CD (1995) Statistical Parametric Maps in functional imaging: A general linear approach.. Hum Brain Mapp 2: 189-210.
  33. Talairach J, Tournoux P (1988) . Co-planar Stereotaxic Atlas of the Human BrainThieme Medical Publishers. New York.
  34. Collins DL, Holmes CJ, Peters TM, Evans AC (1995) Automatic 3-D model-based neuroanatomical segmentation.. Hum Brain Mapp 3: 190-208.
  35. Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS (2000) Automated Talairach Atlas labels for functional brain mapping.. Hum Brain Mapp 10: 120-131.
Copyright 2014 © Nora d. Volkow, Joanna s. Fowler, Gene-jack Wang, Frank Telang, Jean Logan, Christopher Wong, Jim Ma, Kith Pradhan, Helene Benveniste, James m. Swanson. This pubcast is licensed under the terms of the Creative Commons Attribution License 3.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.