JCB's videos (82)

Jun 12, 2012
T cell signaling goes with the flow

Activated T cell receptors stimulate actin polymerization at the periphery of the immunological synapses that form...

May 14, 2012
A new way forward for fibroblasts

Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge, but how...

May 1, 2012
PI3K's Pivotal Role in Cell Migration

Phosphoinositide 3-kinase (PI3K) and its phospholipid products are polarized toward the front of migrating...

Mar 20, 2012
Vinculin minds the endothelial gap

The adhesions between endothelial cells transiently remodel in response to angiogenic growth factors and inflammatory...

Feb 21, 2012
Neuronal autophagosomes mature on the move

Autophagy is a cellular degradation pathway essential for neuronal survival, but little is known about the dynamics...

Jan 23, 2012
Septins rein in the membrane

T cells require the septin family of GTP-binding proteins to maintain the integrity of their plasma membranes as they...

Jan 9, 2012
A Twin-Track Approach to Building Desmosomes

Desmosomes are intercellular adhesions whose adhesive core is formed by two distinct classes of cadherin molecules --...

Nov 29, 2011
CKIδ Decentralizes the Centrosome

When a T cell encounters a target antigen-presenting cell, the lymphocyte's centrosome relocalizes to a specialized...

Oct 31, 2011
Cofilin severs the ties between cytokinetic nodes

Cytokinetic nodes are precursor structures that assemble into the actomyosin contractile ring that separates daughter...

Oct 3, 2011
Moesin keeps mitotic cells in shape

The ERM protein Moesin helps mitotic cells undergo a series of dramatic shape changes by linking the actin...

Sep 9, 2011
Actin puts the squeeze on Weibel-Palade bodies

The actin cytoskeleton has been proposed to regulate exocytosis in many different ways. Nightingale et al. use a...

Aug 10, 2011
Nuclear envelope starts with a clean sheet

At the start of mitosis, the nuclear envelope and nuclear pore complexes break down and disperse into the endoplasmic...

Jul 11, 2011
Oocyte microtubules show their bias

Several mRNAs are specifically transported to the anterior and posterior regions of Drosophila oocytes by...

Jun 13, 2011
Tying the Golgi Ribbon to the Centrosome

The mammalian Golgi apparatus exists as a continuous ribbon that clusters around the centrosome, but the significance...