JCB's videos (66)


1076
Mar 22, 2011
Nup133 is a Pore Relation to the Centrosome

The centrosome remains closely associated with the nucleus throughout the cell cycle. Bolhy et al. reveal that the...

955
Feb 23, 2011
Curbing the Killer Instinct

Natural Killer (NK) cells distinguish target cells from surrounding healthy tissue by integrating signals from a...

1127
Jan 24, 2011
Microtubules Keep Tumor Cells Breathing Easy

The transcription factor HIF-1α is essential for a cell's response to low oxygen conditions. Carbonaro et al....

903
Jan 5, 2011
The Spindle's Model Behavior

Dynamic microtubules assemble into a steady state bipolar spindle structure but precisely how this is achieved is...

975
Nov 29, 2010
Seeing organelles live in concert

Centrosome positioning is thought to be important for both neuronal migration and axonogenesis. To investigate...

1203
Nov 2, 2010
Pulling centrosomes to the forward position

Most migrating cells place their centrosome in front of the nucleus, facing the direction in which the cell is...

1294
Oct 5, 2010
Dynein and kinesin generate nuclear power

Many cellular processes, including polarization and differentiation, require the nucleus to move to a specific...

1168
Sep 14, 2010
T Cells Rho across the endothelium

During an immune response, T cells move into tissues from the vasculature by crossing the endothelial cell layer...

1183
Aug 11, 2010
Acetylated microtubules let the ER slide

The endoplasmic reticulum is highly dynamic, although little is known about why and how its membrane tubules move....

1828
Jul 16, 2010
Long Asters Rock The Spindle

Astral microtubules help position the cytokinetic furrow by confining actomyosin contractility to the cell equator....

1768
Jun 15, 2010
Laminin Adhesions Help Microtubules Reach Base

Microtubules align along the apical-basal axis of epithelial cells with their plus ends pointing to the basal side....

1503
May 27, 2010
A Turning Point for Macrophages

Drosophila macrophages disperse themselves around the body during embryogenesis, ready to mount an immune response at...

1646
Apr 20, 2010
CyclinB1-Cdk1 Makes Its Move

Cells drastically alter their structure at the onset of mitosis. Gavet and Pines reveal that the mitotic kinase...

1498
Mar 22, 2010
Integrating the forces that fold tissues

During gastrulation, pulsed contractions of the actomyosin cytoskeleton apically constrict a strip of cells on the...