JCB's videos (78)


507
Apr 17, 2013
biosights: April 15, 2013 - Frog oocytes evade the checkpoint

Most dividing cells possess a spindle assembly checkpoint that prevents them from entering anaphase until all their...

731
Mar 21, 2013
biosights: March 18, 2013 - Breaking egg symmetry

During the first meiotic division of mammalian oocytes, the meiotic spindle and chromosomes move from the interior to...

562
Feb 21, 2013
biosights: February 18, 2013 - Erecting a myosin scaffold for cytokinesis

Cell division requires the coordinated action of proteins that promote actomyosin contraction, membrane trafficking,...

544
Jan 28, 2013
biosights: January 21, 2013 - How cell shape changes unfold

Under certain conditions, cells form protrusions that oscillate rapidly around the cell periphery. Kapustina et al....

537
Jan 4, 2013
biosights: Decemeber 24, 2012 - Global sourcing for cytokinetic ring assembly

At the end of cytokinesis, the microtubule-rich midbody connecting the daughter cells is either shed into the...

465
Nov 27, 2012
biosights: November 26, 2012 - Global sourcing for cytokinetic ring assembly

Fission yeast are thought to assemble their cytokinetic actomyosin rings from actin filaments nucleated at...

616
Nov 12, 2012
biosights: October 29, 2012 - A stiff test for collectively migrating cells

The mechanical properties of the extracellular matrix are known to regulate the migration of single cells, but...

602
Oct 1, 2012
biosights: October 1, 2012 - Cortical dynein puts the spindle in its place

The position of the mitotic spindle is controlled by the microtubule-based motor dynein and a ternary complex of the...

592
Aug 8, 2012
biosights: August 6, 2012 - Redistribution aids the pore

In animal cells, the nuclear lamina keeps nuclear pore complexes evenly distributed throughout the nuclear envelope....

544
Jul 9, 2012
Asters help embryonic nuclei find their own space

In early Drosophila embryos, nuclei undergo rapid, synchronous divisions without being separated into individual...

587
Jun 12, 2012
T cell signaling goes with the flow

Activated T cell receptors stimulate actin polymerization at the periphery of the immunological synapses that form...

625
May 14, 2012
A new way forward for fibroblasts

Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge, but how...

549
May 1, 2012
PI3K's Pivotal Role in Cell Migration

Phosphoinositide 3-kinase (PI3K) and its phospholipid products are polarized toward the front of migrating...

405
Mar 20, 2012
Vinculin minds the endothelial gap

The adhesions between endothelial cells transiently remodel in response to angiogenic growth factors and inflammatory...