JCB's videos (71)


548
Oct 1, 2012
biosights: October 1, 2012 - Cortical dynein puts the spindle in its place

The position of the mitotic spindle is controlled by the microtubule-based motor dynein and a ternary complex of the...

547
Aug 8, 2012
biosights: August 6, 2012 - Redistribution aids the pore

In animal cells, the nuclear lamina keeps nuclear pore complexes evenly distributed throughout the nuclear envelope....

517
Jul 9, 2012
Asters help embryonic nuclei find their own space

In early Drosophila embryos, nuclei undergo rapid, synchronous divisions without being separated into individual...

527
Jun 12, 2012
T cell signaling goes with the flow

Activated T cell receptors stimulate actin polymerization at the periphery of the immunological synapses that form...

565
May 14, 2012
A new way forward for fibroblasts

Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge, but how...

490
May 1, 2012
PI3K's Pivotal Role in Cell Migration

Phosphoinositide 3-kinase (PI3K) and its phospholipid products are polarized toward the front of migrating...

376
Mar 20, 2012
Vinculin minds the endothelial gap

The adhesions between endothelial cells transiently remodel in response to angiogenic growth factors and inflammatory...

368
Feb 21, 2012
Neuronal autophagosomes mature on the move

Autophagy is a cellular degradation pathway essential for neuronal survival, but little is known about the dynamics...

489
Jan 23, 2012
Septins rein in the membrane

T cells require the septin family of GTP-binding proteins to maintain the integrity of their plasma membranes as they...

420
Jan 9, 2012
A Twin-Track Approach to Building Desmosomes

Desmosomes are intercellular adhesions whose adhesive core is formed by two distinct classes of cadherin molecules --...

407
Nov 29, 2011
CKIδ Decentralizes the Centrosome

When a T cell encounters a target antigen-presenting cell, the lymphocyte's centrosome relocalizes to a specialized...

415
Oct 31, 2011
Cofilin severs the ties between cytokinetic nodes

Cytokinetic nodes are precursor structures that assemble into the actomyosin contractile ring that separates daughter...

549
Oct 3, 2011
Moesin keeps mitotic cells in shape

The ERM protein Moesin helps mitotic cells undergo a series of dramatic shape changes by linking the actin...

639
Sep 9, 2011
Actin puts the squeeze on Weibel-Palade bodies

The actin cytoskeleton has been proposed to regulate exocytosis in many different ways. Nightingale et al. use a...