JCB's videos (63)


446
Jan 28, 2013
biosights: January 21, 2013 - How cell shape changes unfold

Under certain conditions, cells form protrusions that oscillate rapidly around the cell periphery. Kapustina et al....

439
Jul 9, 2012
Asters help embryonic nuclei find their own space

In early Drosophila embryos, nuclei undergo rapid, synchronous divisions without being separated into individual...

408
Sep 30, 2013
biosights: September 30, 2013 - The nodal network

In addition to specialized actin structures such as lamellipodia and stress fibers, cells are thought to contain a...

405
Apr 17, 2013
biosights: April 15, 2013 - Frog oocytes evade the checkpoint

Most dividing cells possess a spindle assembly checkpoint that prevents them from entering anaphase until all their...

405
Jan 23, 2012
Septins rein in the membrane

T cells require the septin family of GTP-binding proteins to maintain the integrity of their plasma membranes as they...

403
May 1, 2012
PI3K's Pivotal Role in Cell Migration

Phosphoinositide 3-kinase (PI3K) and its phospholipid products are polarized toward the front of migrating...

399
Jan 21, 2014
biosights: January 20, 2014 - Motors give a new twist to platelet activation

The discoid shape of resting platelets is maintained by a peripheral ring of bundled microtubules called the marginal...

391
Feb 21, 2013
biosights: February 18, 2013 - Erecting a myosin scaffold for cytokinesis

Cell division requires the coordinated action of proteins that promote actomyosin contraction, membrane trafficking,...

365
Jul 16, 2013
biosights: July 8, 2013 - Vinculin delivers a clutch performance

At the leading edge of migrating cells, actin assembly and membrane protrusion are closely coupled with the formation...

352
Oct 28, 2013
biosights: October 28, 2013 - A framework for understanding muscle microtubules

The microtubules of skeletal muscle fibers are arranged into an orthogonal grid, but how this network is formed is...

351
Dec 23, 2013
biosights: Decemeber 23, 2013 - Tumor cells WASH away the extracellular matrix

Tumor cells invade through extracellular matrices by forming actin-rich structures called invadopodia, which contain...

346
Aug 6, 2013
biosights: August 5, 2013 - Epithelia restored by healing waves

Epithelial cells around the edge of a wound assemble an actomyosin cable that constricts to draw the wound closed,...

344
Jun 12, 2012
T cell signaling goes with the flow

Activated T cell receptors stimulate actin polymerization at the periphery of the immunological synapses that form...

340
Oct 31, 2011
Cofilin severs the ties between cytokinetic nodes

Cytokinetic nodes are precursor structures that assemble into the actomyosin contractile ring that separates daughter...