JCB's videos (82)

May 14, 2012
A new way forward for fibroblasts

Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge, but how...

Jan 20, 2015
biosights: January 19, 2015 - Tubulin transport pumps up cilia

The assembly of cilia and flagella requires the delivery of large amounts of tubulin to the growing ends of the...

Oct 1, 2012
biosights: October 1, 2012 - Cortical dynein puts the spindle in its place

The position of the mitotic spindle is controlled by the microtubule-based motor dynein and a ternary complex of the...

Nov 12, 2012
biosights: October 29, 2012 - A stiff test for collectively migrating cells

The mechanical properties of the extracellular matrix are known to regulate the migration of single cells, but...

Aug 4, 2014
biosights: August 4, 2014 - Rok keeps its finger on the pulse of apical...

Early in Drosophila embryogenesis, contractile pulses of myosin assembly and disassembly constrict the apical domains...

Aug 8, 2012
biosights: August 6, 2012 - Redistribution aids the pore

In animal cells, the nuclear lamina keeps nuclear pore complexes evenly distributed throughout the nuclear envelope....

Jun 12, 2012
T cell signaling goes with the flow

Activated T cell receptors stimulate actin polymerization at the periphery of the immunological synapses that form...

Oct 3, 2011
Moesin keeps mitotic cells in shape

The ERM protein Moesin helps mitotic cells undergo a series of dramatic shape changes by linking the actin...

Feb 21, 2013
biosights: February 18, 2013 - Erecting a myosin scaffold for cytokinesis

Cell division requires the coordinated action of proteins that promote actomyosin contraction, membrane trafficking,...

Oct 28, 2013
biosights: October 28, 2013 - A framework for understanding muscle microtubules

The microtubules of skeletal muscle fibers are arranged into an orthogonal grid, but how this network is formed is...

Dec 23, 2013
biosights: Decemeber 23, 2013 - Tumor cells WASH away the extracellular matrix

Tumor cells invade through extracellular matrices by forming actin-rich structures called invadopodia, which contain...

Jan 4, 2013
biosights: Decemeber 24, 2012 - Global sourcing for cytokinetic ring assembly

At the end of cytokinesis, the microtubule-rich midbody connecting the daughter cells is either shed into the...

May 1, 2012
PI3K's Pivotal Role in Cell Migration

Phosphoinositide 3-kinase (PI3K) and its phospholipid products are polarized toward the front of migrating...

Feb 19, 2015
biosights: February 16, 2015 - Filopodia point the way for haptotaxis

Migrating fibroblasts maintain or change their direction by branching off new lamellipodia from existing protrusions...