JCB's videos (76)

Feb 18, 2014
biosights: February 17, 2014 - Shroom takes embryos to new dimensions

During development, the planar polarized distribution of Rho kinase and Myosin II helps Drosophila germ-band cells...

Jun 11, 2013
biosights: June 10, 2013 - Netrin Throws Anchor Cells into the Breach

Cell invasion through basement membranes is crucial for both normal development and cancer metastasis but relatively...

Jul 16, 2013
biosights: July 8, 2013 - Vinculin delivers a clutch performance

At the leading edge of migrating cells, actin assembly and membrane protrusion are closely coupled with the formation...

Oct 1, 2012
biosights: October 1, 2012 - Cortical dynein puts the spindle in its place

The position of the mitotic spindle is controlled by the microtubule-based motor dynein and a ternary complex of the...

Aug 8, 2012
biosights: August 6, 2012 - Redistribution aids the pore

In animal cells, the nuclear lamina keeps nuclear pore complexes evenly distributed throughout the nuclear envelope....

Aug 4, 2014
biosights: August 4, 2014 - Rok keeps its finger on the pulse of apical...

Early in Drosophila embryogenesis, contractile pulses of myosin assembly and disassembly constrict the apical domains...

Oct 3, 2011
Moesin keeps mitotic cells in shape

The ERM protein Moesin helps mitotic cells undergo a series of dramatic shape changes by linking the actin...

Jan 20, 2015
biosights: January 19, 2015 - Tubulin transport pumps up cilia

The assembly of cilia and flagella requires the delivery of large amounts of tubulin to the growing ends of the...

Jun 12, 2012
T cell signaling goes with the flow

Activated T cell receptors stimulate actin polymerization at the periphery of the immunological synapses that form...

Dec 23, 2013
biosights: Decemeber 23, 2013 - Tumor cells WASH away the extracellular matrix

Tumor cells invade through extracellular matrices by forming actin-rich structures called invadopodia, which contain...

Sep 30, 2013
biosights: September 30, 2013 - The nodal network

In addition to specialized actin structures such as lamellipodia and stress fibers, cells are thought to contain a...

Jan 28, 2013
biosights: January 21, 2013 - How cell shape changes unfold

Under certain conditions, cells form protrusions that oscillate rapidly around the cell periphery. Kapustina et al....

May 1, 2012
PI3K's Pivotal Role in Cell Migration

Phosphoinositide 3-kinase (PI3K) and its phospholipid products are polarized toward the front of migrating...

Jul 9, 2012
Asters help embryonic nuclei find their own space

In early Drosophila embryos, nuclei undergo rapid, synchronous divisions without being separated into individual...