JCB's videos (77)

Jul 11, 2011
Oocyte microtubules show their bias

Several mRNAs are specifically transported to the anterior and posterior regions of Drosophila oocytes by...

Feb 23, 2011
Curbing the Killer Instinct

Natural Killer (NK) cells distinguish target cells from surrounding healthy tissue by integrating signals from a...

Jan 5, 2011
The Spindle's Model Behavior

Dynamic microtubules assemble into a steady state bipolar spindle structure but precisely how this is achieved is...

May 16, 2011
Ouch! Single Cell Wound Repair in Drosophila Embryos

Individual cells must quickly repair any disruptions to their plasma membrane. Abreu-Blanco et al. describe how early...

May 15, 2013
biosights: May 13, 2013 - Ventral lamellipodia plug the gaps

When leukocytes enter or exit the blood stream, they leave small wounds both in and between the vascular endothelial...

Mar 24, 2014
biosights: March 17, 2014 - Blebs lead the way in Dictyostelium chemotaxis

Membrane blebs can help the leading edge of migrating cells protrude forwards, but the contribution of blebs to the...

Sep 3, 2013
biosights: September 2, 2013 - Shrinking microtubules pull the centrosome...

When a T cell encounters a target antigen-presenting cell, it moves its centrosome to the immunological synapse that...

Oct 27, 2014
biosights: October 27, 2014 - Epithelial cells make changes at the top

The apical surfaces of polarized epithelia are covered by short, actin-rich protrusions called microvilli, but what...

Jan 5, 2015
biosights: December 22, 2014 - Osmotic gradient is just the tonic for wounded...

Rapid wound repair is generally thought to be initiated by intrinsic cues, such as changes in the structure or...

Mar 21, 2013
biosights: March 18, 2013 - Breaking egg symmetry

During the first meiotic division of mammalian oocytes, the meiotic spindle and chromosomes move from the interior to...

Sep 9, 2011
Actin puts the squeeze on Weibel-Palade bodies

The actin cytoskeleton has been proposed to regulate exocytosis in many different ways. Nightingale et al. use a...

Jan 21, 2014
biosights: January 20, 2014 - Motors give a new twist to platelet activation

The discoid shape of resting platelets is maintained by a peripheral ring of bundled microtubules called the marginal...

May 14, 2012
A new way forward for fibroblasts

Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge, but how...

Nov 12, 2012
biosights: October 29, 2012 - A stiff test for collectively migrating cells

The mechanical properties of the extracellular matrix are known to regulate the migration of single cells, but...