JCB's videos (66)


905
Jan 5, 2011
The Spindle's Model Behavior

Dynamic microtubules assemble into a steady state bipolar spindle structure but precisely how this is achieved is...

891
Nov 25, 2013
biosights: November 25, 2013 - Caspases work as branch managers

When a growing axon nears its target, it arborizes, or branches, to form numerous synaptic connections. Campbell and...

880
May 16, 2011
Ouch! Single Cell Wound Repair in Drosophila Embryos

Individual cells must quickly repair any disruptions to their plasma membrane. Abreu-Blanco et al. describe how early...

852
May 15, 2013
biosights: May 13, 2013 - Ventral lamellipodia plug the gaps

When leukocytes enter or exit the blood stream, they leave small wounds both in and between the vascular endothelial...

735
Mar 24, 2014
biosights: March 17, 2014 - Blebs lead the way in Dictyostelium chemotaxis

Membrane blebs can help the leading edge of migrating cells protrude forwards, but the contribution of blebs to the...

729
Sep 3, 2013
biosights: September 2, 2013 - Shrinking microtubules pull the centrosome...

When a T cell encounters a target antigen-presenting cell, it moves its centrosome to the immunological synapse that...

666
Mar 21, 2013
biosights: March 18, 2013 - Breaking egg symmetry

During the first meiotic division of mammalian oocytes, the meiotic spindle and chromosomes move from the interior to...

588
Sep 9, 2011
Actin puts the squeeze on Weibel-Palade bodies

The actin cytoskeleton has been proposed to regulate exocytosis in many different ways. Nightingale et al. use a...

541
Jun 11, 2013
biosights: June 10, 2013 - Netrin Throws Anchor Cells into the Breach

Cell invasion through basement membranes is crucial for both normal development and cancer metastasis but relatively...

536
Jan 21, 2014
biosights: January 20, 2014 - Motors give a new twist to platelet activation

The discoid shape of resting platelets is maintained by a peripheral ring of bundled microtubules called the marginal...

513
May 14, 2012
A new way forward for fibroblasts

Fibroblasts moving across two-dimensional surfaces form lamellipodial protrusions at their leading edge, but how...

509
Nov 12, 2012
biosights: October 29, 2012 - A stiff test for collectively migrating cells

The mechanical properties of the extracellular matrix are known to regulate the migration of single cells, but...

509
Oct 1, 2012
biosights: October 1, 2012 - Cortical dynein puts the spindle in its place

The position of the mitotic spindle is controlled by the microtubule-based motor dynein and a ternary complex of the...

496
Oct 3, 2011
Moesin keeps mitotic cells in shape

The ERM protein Moesin helps mitotic cells undergo a series of dramatic shape changes by linking the actin...