JCB's Videos

Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge
Chemoattractant signaling induces the polarization and directed movement of cells secondary to the activation of multiple effector pathways. In addition, chemotactic signals can be amplified and...

4818 views since Apr 22, 2009 09:14

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One-Dimensional Topography Underlies Three-Dimensional Fibrillar Cell Migration
Current concepts of cell migration were established in regular two-dimensional (2D) cell culture, but the roles of topography are poorly understood for cells migrating in an oriented 3D fibrillar...

2883 views since Apr 22, 2009 10:19

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Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis
The establishment of apical–basal polarity within a single cell and throughout a growing tissue is a key feature of epithelial morphogenesis. To examine the underlying mechanisms, the human...

2772 views since Apr 22, 2009 11:10

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Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown
Cell adhesion to the extracellular matrix is mediated by elaborate networks of multiprotein complexes consisting of adhesion receptors, cytoskeletal components, signaling molecules, and diverse...

2651 views since Aug 11, 2009 08:24

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DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos
We examined the contribution of S phase in timing cell cycle progression during Drosophila embryogenesis using an approach that deletes S phase rather than arresting its progress. Injection of...

2489 views since Oct 22, 2009 15:03

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Motor-dependent microtubule disassembly driven by tubulin tyrosination
In cells, stable microtubules (MTs) are covalently modified by a carboxypeptidase, which removes the C-terminal Tyr residue of alpha-tubulin. The significance of this selective detyrosination of...

2217 views since Jul 14, 2009 12:17

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AP-1 and KIF13A coordinate endosomal sorting and positioning during melanosome biogenesis
Specialized cell types exploit endosomal trafficking to deliver protein cargoes to cell type–specific lysosome-related organelles (LROs), but how endosomes are specified for this function is not...

1922 views since Nov 2, 2009 09:23

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The Dictyostelium type V myosin MyoJ is responsible for the cortical association and motility of contractile vacuole membranes
The contractile vacuole (CV) complex in Dictyostelium is a tubulovesicular osmoregulatory organelle that exhibits extensive motility along the actin-rich cortex, providing a useful model for...

1794 views since Oct 22, 2009 13:27

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Systems biology of the mitotic spindle
A novel high-throughput screening approach that combines yeast mutant arrays with high-content imaging provides fresh insights into mitotic spindle disassembly. This biosights episode presents the...

1463 views since Jan 28, 2010 08:21

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Probing the spindle matrix
A microtubule-independent network of proteins called the spindle matrix is involved in assembling mitotic and meiotic spindles, but whether the matrix makes a mechanical contribution to spindle...

1451 views since Feb 24, 2010 07:37

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