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Septins rein in the membrane
T cells require the septin family of GTP-binding proteins to maintain the integrity of their plasma membranes as they invade through tissues. Gilden et al. reveal that septins function by...
T cells require the septin family of GTP-binding proteins to maintain the integrity of their plasma membranes as they invade through tissues. Gilden et al. reveal that septins function by...
102 views since Jan 23, 2012 13:02
A Twin-Track Approach to Building Desmosomes
Desmosomes are intercellular adhesions whose adhesive core is formed by two distinct classes of cadherin molecules -- desmogleins and desmocollins. Nekrasova et al. reveal that these two cadherins...
Desmosomes are intercellular adhesions whose adhesive core is formed by two distinct classes of cadherin molecules -- desmogleins and desmocollins. Nekrasova et al. reveal that these two cadherins...
78 views since Jan 9, 2012 12:15
CKIδ Decentralizes the Centrosome
When a T cell encounters a target antigen-presenting cell, the lymphocyte's centrosome relocalizes to a specialized contact between the two cells called the immunological synapse. Zyss et al....
When a T cell encounters a target antigen-presenting cell, the lymphocyte's centrosome relocalizes to a specialized contact between the two cells called the immunological synapse. Zyss et al....
63 views since Nov 29, 2011 10:31
Cofilin severs the ties between cytokinetic nodes
Cytokinetic nodes are precursor structures that assemble into the actomyosin contractile ring that separates daughter cells in cytokinesis. Chen and Pollard describe how the actin-severing protein...
Cytokinetic nodes are precursor structures that assemble into the actomyosin contractile ring that separates daughter cells in cytokinesis. Chen and Pollard describe how the actin-severing protein...
135 views since Oct 31, 2011 11:40
Moesin keeps mitotic cells in shape
The ERM protein Moesin helps mitotic cells undergo a series of dramatic shape changes by linking the actin cytoskeleton to the plasma membrane. Roubinet et al. describe how Moesin's localization...
The ERM protein Moesin helps mitotic cells undergo a series of dramatic shape changes by linking the actin cytoskeleton to the plasma membrane. Roubinet et al. describe how Moesin's localization...
301 views since Oct 3, 2011 11:53
Actin puts the squeeze on Weibel-Palade bodies
The actin cytoskeleton has been proposed to regulate exocytosis in many different ways. Nightingale et al. use a two-color, live-cell imaging assay to reveal two contrasting functions of actin in...
The actin cytoskeleton has been proposed to regulate exocytosis in many different ways. Nightingale et al. use a two-color, live-cell imaging assay to reveal two contrasting functions of actin in...
324 views since Sep 9, 2011 13:26
Nuclear envelope starts with a clean sheet
At the start of mitosis, the nuclear envelope and nuclear pore complexes break down and disperse into the endoplasmic reticulum and cytoplasm. Lu et al. use rapid, 3D live cell imaging to reveal...
At the start of mitosis, the nuclear envelope and nuclear pore complexes break down and disperse into the endoplasmic reticulum and cytoplasm. Lu et al. use rapid, 3D live cell imaging to reveal...
617 views since Aug 10, 2011 13:12
Oocyte microtubules show their bias
Several mRNAs are specifically transported to the anterior and posterior regions of Drosophila oocytes by microtubule-based motor proteins, but the organization of microtubules in these cells is...
Several mRNAs are specifically transported to the anterior and posterior regions of Drosophila oocytes by microtubule-based motor proteins, but the organization of microtubules in these cells is...
615 views since Jul 11, 2011 10:59
Tying the Golgi Ribbon to the Centrosome
The mammalian Golgi apparatus exists as a continuous ribbon that clusters around the centrosome, but the significance of this organization is unclear. Hurtado et al. identify truncation mutants of...
The mammalian Golgi apparatus exists as a continuous ribbon that clusters around the centrosome, but the significance of this organization is unclear. Hurtado et al. identify truncation mutants of...
660 views since Jun 13, 2011 13:11
Ouch! Single Cell Wound Repair in Drosophila Embryos
Individual cells must quickly repair any disruptions to their plasma membrane. Abreu-Blanco et al. describe how early Drosophila embryos remodel their membranes and cytoskeleton to seal cell...
Individual cells must quickly repair any disruptions to their plasma membrane. Abreu-Blanco et al. describe how early Drosophila embryos remodel their membranes and cytoskeleton to seal cell...
617 views since May 16, 2011 13:00
