JCB's videos (71)

Nov 25, 2014
biosights: November 24, 2014 - Dynein helps centrioles stick together

Dynein has numerous functions in mitosis, but the function of the motor complex's light intermediate chains is poorly...

Oct 27, 2014
biosights: October 27, 2014 - Epithelial cells make changes at the top

The apical surfaces of polarized epithelia are covered by short, actin-rich protrusions called microvilli, but what...

Sep 30, 2014
biosights: September 29, 2014 - Cdc42 prompts a change of heart

The Drosophila heart is a simple tubular structure with a central lumen. Vogler et al. reveal that the small GTPase...

Sep 3, 2014
biosights: September 1, 2014 - Deploying exosomes in a battle of the sexes

The paired accessory glands of male Drosophila secrete multiple signaling factors into the seminal fluid that promote...

Aug 4, 2014
biosights: August 4, 2014 - Rok keeps its finger on the pulse of apical...

Early in Drosophila embryogenesis, contractile pulses of myosin assembly and disassembly constrict the apical domains...

Jul 8, 2014
biosights: July 7, 2014 - The fluid dynamics of collective cell migration

During development and tumor metastasis, cells prepare to migrate by undergoing an epithelial-to-mesenchymal...

Jun 12, 2014
biosights: June 9, 2014 - Rab18 tilts the balance of ER structure

The endoplasmic reticulum consists of peripheral tubular networks connected to sheet-like domains surrounding the...

May 12, 2014
biosights: May 12, 2014 - Phosphoinositides get cells in shape

Early Drosophila embryos undergo 13 rounds of rapid nuclear division before enclosing each nucleus into an...

Apr 14, 2014
biosights: April 14, 2014 - An actin lever flattens out the cell

The lamella is a broad, flat region that forms at the front of migrating cells and adheres to the underlying...

Mar 24, 2014
biosights: March 17, 2014 - Blebs lead the way in Dictyostelium chemotaxis

Membrane blebs can help the leading edge of migrating cells protrude forwards, but the contribution of blebs to the...

Feb 18, 2014
biosights: February 17, 2014 - Shroom takes embryos to new dimensions

During development, the planar polarized distribution of Rho kinase and Myosin II helps Drosophila germ-band cells...

Jan 21, 2014
biosights: January 20, 2014 - Motors give a new twist to platelet activation

The discoid shape of resting platelets is maintained by a peripheral ring of bundled microtubules called the marginal...

Dec 23, 2013
biosights: Decemeber 23, 2013 - Tumor cells WASH away the extracellular matrix

Tumor cells invade through extracellular matrices by forming actin-rich structures called invadopodia, which contain...

Nov 25, 2013
biosights: November 25, 2013 - Caspases work as branch managers

When a growing axon nears its target, it arborizes, or branches, to form numerous synaptic connections. Campbell and...