JCB's videos (79)


245
Jul 6, 2015
biosights: July 6, 2015 - Interphase centrosomes flare up

Centrosomes undergo dramatic changes in size and structure during the rapid cell cycles of early Drosophila embryos....

124
Jun 8, 2015
biosights: June 8, 2015 - Melanosomal cargoes BLOC'd off from alternate routes

The BLOC-2 complex contains three subunits encoded by genes mutated in Hermansky-Pudlak syndrome, a disease caused by...

163
May 11, 2015
biosights: May 11, 2015 - Formin' actin at adherens junctions

Actin assembly promotes the formation of intercellular adherens junctions, but the role of actin-nucleating formin...

256
Apr 30, 2015
biosights: April 13, 2015 - A motif that helps myosin II-B lead from behind

Myosin II-A and myosin II-B play distinct roles in establishing the front–back polarity of migrating mesenchymal...

414
Mar 18, 2015
biosights: March 16, 2015 - PAPC separates tissues at a Snail's pace

Brachet's cleft separates the ectoderm and mesoderm of early Xenopus and zebrafish embryos. Luu et al. reveal that,...

532
Feb 19, 2015
biosights: February 16, 2015 - Filopodia point the way for haptotaxis

Migrating fibroblasts maintain or change their direction by branching off new lamellipodia from existing protrusions...

621
Jan 20, 2015
biosights: January 19, 2015 - Tubulin transport pumps up cilia

The assembly of cilia and flagella requires the delivery of large amounts of tubulin to the growing ends of the...

790
Jan 5, 2015
biosights: December 22, 2014 - Osmotic gradient is just the tonic for wounded...

Rapid wound repair is generally thought to be initiated by intrinsic cues, such as changes in the structure or...

341
Nov 25, 2014
biosights: November 24, 2014 - Dynein helps centrioles stick together

Dynein has numerous functions in mitosis, but the function of the motor complex's light intermediate chains is poorly...

802
Oct 27, 2014
biosights: October 27, 2014 - Epithelial cells make changes at the top

The apical surfaces of polarized epithelia are covered by short, actin-rich protrusions called microvilli, but what...

473
Sep 30, 2014
biosights: September 29, 2014 - Cdc42 prompts a change of heart

The Drosophila heart is a simple tubular structure with a central lumen. Vogler et al. reveal that the small GTPase...

1318
Sep 3, 2014
biosights: September 1, 2014 - Deploying exosomes in a battle of the sexes

The paired accessory glands of male Drosophila secrete multiple signaling factors into the seminal fluid that promote...

613
Aug 4, 2014
biosights: August 4, 2014 - Rok keeps its finger on the pulse of apical...

Early in Drosophila embryogenesis, contractile pulses of myosin assembly and disassembly constrict the apical domains...

388
Jul 8, 2014
biosights: July 7, 2014 - The fluid dynamics of collective cell migration

During development and tumor metastasis, cells prepare to migrate by undergoing an epithelial-to-mesenchymal...