video_collector's Publications

Genes and Cells that Determine the Lifespan of C. elegans - Part 2: The Regulation of Aging by Signals from the Reproductive System, and, also, a Link Between Aging and Tumor Growth (37:16)
Once it was thought that aging was just a random and haphazard process. Instead, the rate of aging turns out to be subject to regulation by transcription factors that respond to hormones and other...

Polyketide Biosynthesis: The Erythromycin Example - Part 3: Enzymology of Erythromycin Polyketide Biosynthesis (42:11)
In the final part, the enzymology of the erythromycin polyketide synthase is discussed.

Polyketide Biosynthesis: The Erythromycin Example - Part 2: Impact of Genetics and Molecular Biology on Understanding and Engineering Erythromycin Biosynthesis (22:44)
In the second part, the contributions of genetics and molecular biology on investigations into erythromycin biosynthesis are summarized. The impact of these fields on biosynthetic engineering is...

Computational Protein Design Part 2: Designing Protein Libraries and an Example of Making a Better Fluorescent Protein (33:50)
In this lecture, I discuss the challenges of designing new proteins that fold into a particular structure or perform a particular function. One method is to computationally design a protein based...

What Genomes Can Tell Us About the Past by Sydney Brenner - Part 2: (42:36)
In the second part of talk, I explore other clues that suggest that genomes are not at equilibrium. Some genes appear to be changing more slowly and these older "fossil" genes in modern day genomes...

The Origin of Vertebrates - Part 3: How Chordates Got Their Chord (19:09)
In Part 3: How chordates got their chord, Marc Kirschner (Harvard Medical School) discusses how the overall body plan of vertebrates, arose from the invertebrates based on knowledge of the...

The Origin of Vertebrates - Part 2: Telling the Back from the Front or What the Chordates Invented (27:47)
In Part 2: Telling the back from the front or what the chordates invented, Marc Kirschner (Harvard Medical School) discusses why we look like invertebrate animals turned upside down, i.e....

Role of the Neural Crest in Vertebrate Development and Evolution: Part 3: The Molecular Control of the Neural Crest Contribution to Craniofacial and Brain Development (36:10)
Further studies have shown that the NC cells which participate in facial skeletogenesis correspond to the anteriormost region of the body axis where the genes of the Hox cluster are not expressed....

Role of the Neural Crest in Vertebrate Development and Evolution - Part 2: The Role of the Neural Crest in Head Development and in Vertebrate Evolution (30:04)
Nicole Le Douarin shares her research on the role of the neural crest in skeletal development. The Q/C (quail/chick) marker system revealed that apart from the peripheral nervous system (PNS), the...

The Problem of Regeneration: Part 3: Molecular Basis of Regeneration: Planarians as a Model System (43:54)
In the third and last part of this lecture, I will introduce the model system we have developed to study animal regeneration, the planarian Schmidtea mediterranea. I will review its anatomy, and...