User Profile

mmcguckin


Name
Michael McGuckin
Status:
Professor
Location:
Mater Medical Research Institute
Research Interests:
Mucosal barrier function, mucosal infection, mucosal inflammation, mucin glycoproteins, epithelial cancers, tumour immunology
Affiliations:
Mater Medical Research Institute, The University of Queensland, University of Canberra
Publications in PubMed
  1. Adams RJ, Heazlewood SP, Gilshenan KS, O'Brien M, McGuckin MA, Florin TH. IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin. The American journal of gastroenterology 2008 103(2). DOI:10.1111/j.1572-0241.2007.01577.x.
  2. Pinzon-Charry A, Ho CS, Maxwell T, McGuckin MA, Schmidt C, Furnival C, Pyke CM, López JA. Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer. British journal of cancer 2007 97(9). DOI:10.1038/sj.bjc.6604018.
  3. McGuckin MA, Every AL, Skene CD, Linden SK, Chionh YT, Swierczak A, McAuley J, Harbour S, Kaparakis M, Ferrero R, Sutton P. Muc1 mucin limits both Helicobacter pylori colonization of the murine gastric mucosa and associated gastritis. Gastroenterology 2007 133(4). DOI:10.1053/j.gastro.2007.07.003.
  4. Thornton DJ, Rousseau K, McGuckin MA. Structure and function of the polymeric mucins in airways mucus. Annual review of physiology 2008 70. DOI:10.1146/annurev.physiol.70.113006.100702.
  5. Lindén SK, Driessen KM, McGuckin MA. Improved in vitro model systems for gastrointestinal infection by choice of cell line, pH, microaerobic conditions, and optimization of culture conditions. Helicobacter 2007 12(4). DOI:10.1111/j.1523-5378.2007.00509.x.
  6. Walsh MD, Young JP, Leggett BA, Williams SH, Jass JR, McGuckin MA. The MUC13 cell surface mucin is highly expressed by human colorectal carcinomas. Human pathology 2007 38(6). DOI:10.1016/j.humpath.2006.11.020.
  7. Pinzon-Charry A, Maxwell T, McGuckin MA, Schmidt C, Furnival C, López JA. Spontaneous apoptosis of blood dendritic cells in patients with breast cancer. Breast cancer research : BCR 2006 8(1). DOI:10.1186/bcr1361.
  8. Packer LM, Williams SJ, Callaghan S, Gotley DC, McGuckin MA. Expression of the cell surface mucin gene family in adenocarcinomas. International journal of oncology 2004 25(4). DOI:10.1186/bcr1361.
  9. Raccurt M, Tam SP, Lau P, Mertani HC, Lambert A, Garcia-Caballero T, Li H, Brown RJ, McGuckin MA, Morel G, Waters MJ. Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. British journal of cancer 2003 89(3). DOI:10.1038/sj.bjc.6601115.
  10. Wykes M, MacDonald KP, Tran M, Quin RJ, Xing PX, Gendler SJ, Hart DN, McGuckin MA. MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells. Journal of leukocyte biology 2002 72(4). DOI:10.1038/sj.bjc.6601115.
  11. Cummings MC, Walsh MD, Hohn BG, Bennett IC, Wright RG, McGuckin MA. Occult axillary lymph node metastases in breast cancer do matter: results of 10-year survival analysis. The American journal of surgical pathology 2002 26(10). DOI:10.1038/sj.bjc.6601115.
  12. Obermair A, Schmid BC, Packer LM, Leodolter S, Birner P, Ward BG, Crandon AJ, McGuckin MA, Zeillinger R. Expression of MUC1 splice variants in benign and malignant ovarian tumours. International journal of cancer. Journal international du cancer 2002 100(2). DOI:10.1002/ijc.10456.
  13. Wreschner DH, McGuckin MA, Williams SJ, Baruch A, Yoeli M, Ziv R, Okun L, Zaretsky J, Smorodinsky N, Keydar I, Neophytou P, Stacey M, Lin HH, Gordon S. Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins. Protein science : a publication of the Protein Society 2002 11(3). DOI:10.1002/ijc.10456.
  14. Rye PD, McGuckin MA. MUC1: antibodies and immunoassays. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 22(4). DOI:10.1002/ijc.10456.
  15. Fillippovich I, Sorokina N, Gatei M, Haupt Y, Hobson K, Moallem E, Spring K, Mould M, McGuckin MA, Lavin MF, Khanna KK. Transactivation-deficient p73alpha (p73Deltaexon2) inhibits apoptosis and competes with p53. Oncogene 2001 20(4). DOI:10.1038/sj.onc.1204118.
  16. Quin RJ, McGuckin MA. Phosphorylation of the cytoplasmic domain of the MUC1 mucin correlates with changes in cell-cell adhesion. International journal of cancer. Journal international du cancer 2000 87(4). DOI:10.1038/sj.onc.1204118.
  17. Williams SJ, Wreschner DH, Tran M, Eyre HJ, Sutherland GR, McGuckin MA. Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. The Journal of biological chemistry 2001 276(21). DOI:10.1074/jbc.M008850200.
  18. McGuckin MA, Thornton DJ. Detection and quantitation of mucins using chemical, lectin, and antibody methods. Methods in molecular biology (Clifton, N.J.) 2000 125. DOI:10.1385/1-59259-048-9:045.
  19. Biemer-Hüttmann AE, Walsh MD, McGuckin MA, Simms LA, Young J, Leggett BA, Jass JR. Mucin core protein expression in colorectal cancers with high levels of microsatellite instability indicates a novel pathway of morphogenesis. Clinical cancer research : an official journal of the American Association for Cancer Research 2000 6(5). DOI:10.1385/1-59259-048-9:045.
  20. Walsh MD, Luckie SM, Cummings MC, Antalis TM, McGuckin MA. Heterogeneity of MUC1 expression by human breast carcinoma cell lines in vivo and in vitro. Breast cancer research and treatment 1999 58(3). DOI:10.1385/1-59259-048-9:045.
  21. Williams SJ, McGuckin MA, Gotley DC, Eyre HJ, Sutherland GR, Antalis TM. Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer research 1999 59(16). DOI:10.1385/1-59259-048-9:045.
  22. Biemer-Hüttmann AE, Walsh MD, McGuckin MA, Ajioka Y, Watanabe H, Leggett BA, Jass JR. Immunohistochemical staining patterns of MUC1, MUC2, MUC4, and MUC5AC mucins in hyperplastic polyps, serrated adenomas, and traditional adenomas of the colorectum. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 47(8). DOI:10.1385/1-59259-048-9:045.
  23. Williams SJ, Munster DJ, Quin RJ, Gotley DC, McGuckin MA. The MUC3 gene encodes a transmembrane mucin and is alternatively spliced. Biochemical and biophysical research communications 1999 261(1). DOI:10.1006/bbrc.1999.1001.
  24. Robertson DM, Cahir N, Burger HG, Mamers P, McCloud PI, Pettersson K, McGuckin M. Combined inhibin and CA125 assays in the detection of ovarian cancer. Clinical chemistry 1999 45(5). DOI:10.1006/bbrc.1999.1001.
  25. Richards ER, Devine PL, Quin RJ, Fontenot JD, Ward BG, McGuckin MA. Antibodies reactive with the protein core of MUC1 mucin are present in ovarian cancer patients and healthy women. Cancer immunology, immunotherapy : CII 1998 46(5). DOI:10.1006/bbrc.1999.1001.
  26. McGuckin MA, Quin RJ, Ward BG. Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast cancer cell lines. International journal of oncology 1998 12(4). DOI:10.1006/bbrc.1999.1001.
  27. Dong Y, Walsh MD, Cummings MC, Wright RG, Khoo SK, Parsons PG, McGuckin MA. Expression of MUC1 and MUC2 mucins in epithelial ovarian tumours. The Journal of pathology 1997 183(3). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  28. Dong Y, Walsh MD, McGuckin MA, Cummings MC, Gabrielli BG, Wright GR, Hurst T, Khoo SK, Parsons PG. Reduced expression of retinoblastoma gene product (pRB) and high expression of p53 are associated with poor prognosis in ovarian cancer. International journal of cancer. Journal international du cancer 1997 74(4). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  29. Dong Y, Walsh MD, McGuckin MA, Gabrielli BG, Cummings MC, Wright RG, Hurst T, Khoo SK, Parsons PG. Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product P16INK4A in ovarian cancer is associated with progression and unfavourable prognosis. International journal of cancer. Journal international du cancer 1997 74(1). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  30. McGuckin MA, Devine PL, Ward BG. Early steps in the biosynthesis of MUC2 epithelial mucin in colon cancer cells. Biochemistry and cell biology = Biochimie et biologie cellulaire 1996 74(1). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  31. McGuckin MA, Cummings MC, Walsh MD, Hohn BG, Bennett IC, Wright RG. Occult axillary node metastases in breast cancer: their detection and prognostic significance. British journal of cancer 1996 73(1). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  32. McGuckin MA, Hurst TG, Ward BG. Heterogeneity in production, secretion and glycosylation of MUC1 epithelial mucin by primary cultures of ovarian carcinoma. International journal of cancer. Journal international du cancer 1995 63(3). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  33. Devine PL, Walsh MD, McGuckin MA, Quin RJ, Hohn BG, Clague A, Samaratunga H. Prostate-specific antigen (PSA) and cancer-associated serum antigen (CASA) in distinguishing benign and malignant prostate disease. The International journal of biological markers 10(4). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  34. Devine PL, Duroux MA, Quin RJ, McGuckin MA, Joy GJ, Ward BG, Pollard CW. CA15-3, CASA, MSA, and TPS as diagnostic serum markers in breast cancer. Breast cancer research and treatment 1995 34(3). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  35. Devine PL, McGuckin MA, Quin RJ, Ward BG. Predictive value of the combination of serum markers, CA125, CASA and TPS in ovarian cancer. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 1995 5(3). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  36. McGuckin MA, Walsh MD, Hohn BG, Ward BG, Wright RG. Prognostic significance of MUC1 epithelial mucin expression in breast cancer. Human pathology 1995 26(4). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  37. Clark S, McGuckin MA, Hurst T, Ward BG. Effect of interferon-gamma and TNF-alpha on MUC1 mucin expression in ovarian carcinoma cell lines. Disease markers 1994 12(1). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  38. Clark S, McGuckin MA, Hurst T, Ward BG. Effect of interferon gamma and tumour necrosis factor alpha on sensitivity to cisplatin in ovarian carcinoma cell lines. Cancer immunology, immunotherapy : CII 1994 39(2). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  39. Walsh MD, Hohn BG, Thong W, Devine PL, Gardiner RA, Samaratunga ML, McGuckin MA. Mucin expression by transitional cell carcinomas of the bladder. British journal of urology 1994 73(3). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  40. Ward BG, McGuckin MA. Are CASA and CA125 concentrations in peripheral blood sourced from peritoneal fluid in women with pelvic masses? Cancer 1994 73(6). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  41. McGuckin MA, Devine PL, Ramm LE, Ward BG. Factors effecting the measurement of tumor-associated MUC1 mucins in serum. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1994 15(1). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  42. Devine PL, McGuckin MA, Quin RJ, Ward BG. Serum markers CASA and CA 15-3 in ovarian cancer: all MUC1 assays are not the same. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1994 15(6). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  43. Walsh MD, McGuckin MA, Devine PL, Hohn BG, Wright RG. Expression of MUC2 epithelial mucin in breast carcinoma. Journal of clinical pathology 1993 46(10). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  44. Devine PL, McGuckin MA, Ramm LE, Ward BG, Pee D, Long S. Serum mucin antigens CASA and MSA in tumors of the breast, ovary, lung, pancreas, bladder, colon, and prostate. A blind trial with 420 patients. Cancer 1993 72(6). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  45. Devine PL, McGuckin MA, Ramm LE, Harada H, Ward BG. The use of mucin-specific monoclonal antibodies and lectins in the detection of tumor-associated serum markers in gynecological cancer. Cancer biochemistry biophysics 1993 13(4). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  46. Samaratunga H, Hohn BG, Walsh MD, Gardiner R, Devine PL, McGuckin MA. Mucin inclusions in urothelial carcinomas. Human pathology 1993 24(8). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  47. Devine PL, McGuckin MA, Birrell GW, Whitehead RH, Sachdev GP, Shield P, Ward BG. Monoclonal antibodies reacting with the MUC2 mucin core protein. British journal of cancer 1993 67(6). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  48. McGuckin MA, Ramm LE, Joy GJ, Devine PL, Ward BG. Circulating tumour-associated mucin concentrations, determined by the CASA assay, in healthy women. Clinica chimica acta; international journal of clinical chemistry 1993 214(2). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  49. Ward BG, McGuckin MA, Ramm LE, Coglan M, Sanderson B, Tripcony L, Free KE. The management of ovarian carcinoma is improved by the use of cancer-associated serum antigen and CA 125 assays. Cancer 1993 71(2). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  50. Ward BG, Joy GJ, Ramm LE, Baker CA, McGuckin MA. Comparative study of mammography and mammary serum antigen estimation for breast cancer screening. The Medical journal of Australia 1992 157(3). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  51. McGuckin MA, Ramm LE, Joy GJ, Free KE, Ward BC. Preoperative discrimination between ovarian carcinoma, non-ovarian gynecological malignancy and benign adnexal masses using serum levels of CA125 and the polymorphic epithelial mucin antigens CASA, OSA and MSA. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 1992 2(3). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  52. Devine PL, McGuckin MA, Ward BG. Circulating mucins as tumor markers in ovarian cancer (review). Anticancer research 12(3). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  53. McGuckin MA, Blackshaw AW. Effects of photoperiod on the reproductive physiology of male flying foxes, Pteropus poliocephalus. Reproduction, fertility, and development 1992 4(1). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  54. Ward BG, McGuckin MA, Ramm L, Forbes KL. Expression of tumour markers CA125, CASA and OSA in minimal/mild endometriosis. The Australian&New Zealand journal of obstetrics&gynaecology 1991 31(3). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  55. McGuckin MA, Blackshaw AW. Mating-associated peak in plasma testosterone concentration in wild male grey-headed flying foxes (Pteropus poliocephalus). Journal of reproduction and fertility 1991 92(2). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  56. McGuckin MA, Blackshaw AW. Seasonal changes in testicular size, plasma testosterone concentration and body weight in captive flying foxes (Pteropus poliocephalus and P. scapulatus). Journal of reproduction and fertility 1991 92(2). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  57. McGuckin MA, Wright G, Ward BG. Expression of a polymorphic epithelial mucin antigen defined by the monoclonal antibody BC2 in ovarian carcinoma. Use of the BC2 antibody for the detection of micrometastases. American journal of clinical pathology 1991 96(1). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  58. McGuckin MA, Wright RG, McKenzie IF, Ward BG. Demonstration of two ovarian tumor-associated antigens in primary and metastatic breast, gastric, and colonic tumors. American journal of clinical pathology 1990 94(2). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  59. McGuckin MA, Layton GT, Bailey MJ, Hurst T, Khoo SK, Ward BG. Evaluation of two new assays for tumor-associated antigens, CASA and OSA, found in the serum of patients with epithelial ovarian carcinoma--comparison with CA125. Gynecologic oncology 1990 37(2). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.
  60. Ward BG, McGuckin MA, Hurst TG, Khoo SK. Expression of multiple tumour markers in serum from patients with ovarian carcinoma and healthy women. The Australian&New Zealand journal of obstetrics&gynaecology 1989 29(3 Pt 2). DOI:10.1002/(SICI)1096-9896(199711)183:3<311::AID-PATH917>3.0.CO;2-2.