User Profile

John.Yamauchi


Name
John Yamauchi
Status:
PhD Student
Location:
San Diego, CA
Research Interests:
I am interested in developing advanced therapeutics for terminal diseases. The utilization of databases and technology will be key in the future for providing the correct types of therapeutics to different groups of patients and I would like to develop platforms for showing that this indeed is the case and can be possible.
Affiliations:
ASPET, UC San Diego Entrepreneur Challenge, The La Jolla Music Society and Allegro Associates, UCSD Graduate Student Association, San Diego Venture Group
Publications in PubMed
  1. Radi? Z, Manetsch R, Krasi?ski A, Raushel J, Yamauchi J, Garcia C, Kolb H, Sharpless KB, Taylor P. Molecular basis of interactions of cholinesterases with tight binding inhibitors. Chemico-biological interactions 2005 157-158. DOI:10.1016/j.cbi.2005.10.020.
Publications
Yamauchi J, Nemecz Á, Ho K, Fotsing JR, Weide T, Grimster N, Stump B, Talley TT, Fokin V, Sharpless KB, Taylor P. Ligand design for human nicotinic acetylcholine receptors using in situ freeze-frame click chemistry, Experimental Biology 2010, Anaheim, CA. April 24-28.

Yamauchi J, Nemecz Á, Ho K, Fotsing JR, Weide T, Grimster N, Stump B, Park J, Nayyar D, Talley TT, Fokin V, Sharpless KB, Taylor P. A Structure-guided Design Strategy to Develop Ligands with Subtype Selectivity for Human Nicotinic Acetylcholine Receptors, Experimental Biology 2009, New Orleans, LA. April 18-22

Yamauchi J, Talley TT, Park J, Tomizawa M, Casida J, Harel M, Taylor P. Understanding receptor selectivity and ligand stereochemistry of insecticides and therapeutic agents for nicotinic acetylcholine receptor subtypes, Experimental Biology 2008, San Diego, CA, April 5-9

Radić Z, Garcia C, Yamauchi J, Quinn DM, Taylor P. Conformational changes and catalytic triad reactivity in acetylcholinesterase monitored by intrinsic tryptophan and conjugated acrylodan fluorescence. Experimental Biology 2005, San Diego, CA, April 2 – 6

Radić Z, Yamauchi J, Operana T, Pezzementi L, Taylor P. Conformational Changes in Substrate Bound Acetylcholinesterase Monitored by Intrinsic Tryptophan and Conjugated Acrylodan Fluorescence, USAMRICD Bioscience review 2004, Baltimore, MD, May 2004
History of Education and Employment
Education:
Molecular Pharmacology, Doctoral of Philosophy (2011)
Biomedical Sciences Graduate Program and Skaggs School of Pharmacy and Pharmaceutical Sciences

Bioengineering (Biotechnology) B.S. (2006)
University of California San Diego, Jacob’s School of Engineering

Relevant Experience:
I. Position: Graduate Student Researcher PRESENT
Dr. Palmer Taylor, Dean of Skaggs School of Pharmacy and Pharmaceutical Sciences UCSD, CA
Purpose of project: Develop ligands that are nAChR subtype specific, focusing on a4B2 and a7 subtypes

II. Position: Graduate Student Researcher (Lab Rotation) 01/2007-02/2007
Dr. J. Andrew McCammon HHMI, Department of Chemistry and Biochemistry UCSD, CA
Purpose of project: Learn computational techniques useful in pharmaceutical sciences

III. Position: Graduate Student Researcher (Lab Rotation) 09/2006-12/2006
Dr. Tracy Handel, Skaggs School of Pharmacy and Pharmaceutical Sciences UCSD, CA
Purpose of project: Purify and obtain large amounts of reconstituted human chemokine receptor 2b (CCR2b)

IV. Position: Graduate Student Researcher (Lab Rotation) 06/2006-08/2006
Dr. Roger Tsien HHMI, Department of Pharmacology UCSD, CA
Purpose of project: Develop a non-invasive sensor for cancerous tissue

V. Position: Research Assistant 06/2003-06/2006
Dr. Palmer Taylor, Department of Pharmacology UCSD, CA
Purpose of project: Characterize residues involved in inhibition of Acetylcholinesterase (AChE) in the active site