Patients with thalassemia major (Thal) frequently have low plasma zinc, which has been associated with low bone mass.
The objective was to determine the effect of zinc supplementation on bone mass in patients with Thal.
Forty-two subjects (21 females aged 10-30 y) with Thal and low bone mass were randomly assigned to receive 25 mg Zn/d or placebo. Bone mineral content (BMC) and areal bone mineral density (aBMD) were assessed by using dual-energy X-ray...
Authors: Ellen B. Fung, Janet L. Kwiatkowski, James N. Huang, Ginny Gildengorin, Janet C. King, Elliott P. Vichinsky