The Spindle's Model Behavior

submitted by: JCB
Dynamic microtubules assemble into a steady state bipolar spindle structure but precisely how this is achieved is unclear. Loughlin et al. develop a computational model that predicts how a few key activities organize microtubules in Xenopus meiotic spindles. This biosights episode presents the paper by Loughlin et al. from the December 27, 2010 issue of The Journal of Cell Biology, and includes an interview with author François Nédélec (EMBL, Heidelberg, Germany). Produced by Caitlin...

Uffe Hellsten on the first frog genome, X. tropicalis

submitted by: JGI

DOE JGI's Uffe Hellsten, first author of the April 30, 2010 Science publication about the first amphibian genome to be sequenced, talks about the importance of the African clawed frog.

Phylogeny determined by protein domain content

submitted by: Song
A simple classification scheme that uses only the presence or absence of a protein domain architecture has been used to determine the phylogeny of 174 complete genomes. The method correctly divides the 174 taxa into Archaea, Bacteria, and Eukarya and satisfactorily sorts most of the major groups within these superkingdoms. The most challenging problem involved 119 Bacteria, many of which have reduced genomes. When a weighting factor was used that takes account of difference in genome size...
Authors: Song Yang, Russell f. Doolittle, Philip e. Bourne