Actin puts the squeeze on Weibel-Palade bodies

submitted by: JCB
The actin cytoskeleton has been proposed to regulate exocytosis in many different ways. Nightingale et al. use a two-color, live-cell imaging assay to reveal two contrasting functions of actin in distinct stages of Weibel-Palade body secretion: actin-based anchors inhibit the fusion of these secretory granules with the plasma membrane but, post-fusion, a contractile actin ring squeezes granule content out of the cell. This biosights episode presents the paper by Nightingale et al. from the...