High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: a pilot, randomized, double-blind, placebo-controlled trial

submitted by: Vin_Tangpricha
Background: Vitamin D deficiency contributes to secondary hyperparathyroidism, which occurs early in chronic kidney disease (CKD). Objectives: We aimed to determine whether high-dose cholecalciferol supplementation for 1 y in early CKD is sufficient to maintain optimal vitamin D status (serum 25-hydroxyvitamin D [25(OH)D] concentration $30 ng/mL) and decrease serum parathyroid hormone (PTH). A secondary aim was to determine the effect of cholecalciferol on blood pressure and serum...
Authors: Jessica Alvarez, Jennie Law, Kathryn Coakley, Susu Zughaier, Li Hao, Khadijeh Salles, Haimanot Wasse, Orlando Gutiérrez, Thomas Ziegler, Vin Tangpricha