Science of the Winter Olympic Games: Science of Ice

submitted by: nsf

The science that makes ice slippery also makes the Olympic Winter Games possible. But exactly what makes ice slippery? Ken Golden, a mathematician at the University of Utah, explains how the unique surface of ice makes the slide and glide of winter sports possible.

Provided by the National Science Foundation & NBC Learn

Identifying clinical/translational research cohorts: ascertainment via querying an integrated multi-source database

submitted by: Jamia

Identifying clinical/translational research cohorts: ascertainment via querying an integrated multi-source database

Feb-2013 JAMIA Webinar (UCSD, Division of Biomedical Informatics)

submitted by: Jamia

Clinical Decision Support for Genetically Guided Personalized Medicine: a Systematic Review

Identifying Clinical/Translational Research Cohorts: Ascertainment via Querying an Integrated Multi-Source Database

submitted by: Jamia
Abstract: BACKGROUND: Ascertainment of potential subjects has been a longstanding problem in clinical research. Various methods have been proposed, including using data in electronic health records. However, these methods typically suffer from scaling effects-some methods work well for large cohorts; others work for small cohorts only. OBJECTIVE: We propose a method that provides a simple identification of pre-research cohorts and relies on data available in most states in the USA: merged...

I-CAMP 2010 Australia CIMOPV Friday July 2 Dane McCamey Understanding coherent microscopic spin process

submitted by: icamvid

I-CAMP 2010 Australia CIMOPV Friday July 2 Dane McCamey Understanding coherent microscopic spin process
Parnell Building Rm 222, University of Queensland, Brisbane, Australia
9:15am Friday July 2, 2010

Adhesion, Signaling and Cancer: Part 3: Focal Adhesions as Stress Sensors (30:57)

submitted by: scivee-team
In the third segment of my seminar, I address a new frontier in cell biology, that is how cells respond to mechanical information. Cells and tissues are exposed to physical forces in vivo and excessive mechanical stress leads to a variety of pathological consequences. I describe a system for exposing cells to controlled mechanical stress and discuss the stretch response. We have discovered that the focal adhesion protein, zyxin, is exquisitely sensitive to mechanical stimulation and is...

Adhesion, Signaling and Cancer: Part 2: Discovery and Characterization of a Focal Adhesion Protein Implicated in Tumor Progression (50:54)

submitted by: scivee-team

In the second segment, I describe the identification of the focal adhesion protein, zyxin, by my lab. Recent work revealed that zyxin is down-regulated upon expression of the Ewing sarcoma oncoprotein, EWS-FLI. Loss of zyxin expression results in enhanced cell motility and is also associated with failed apoptotic signaling. Evidence that zyxin shuttles between focal adhesions and the nucleus is presented. The impact of reduced zyxin expression on tumor progression is discussed.

Conus Peptides: Part 3: Conus Peptide Genes a "Drug Development Program" (25.36)

submitted by: scivee-team
Although snails are not the first animals that come to mind when venoms are mentioned, there are in fact a large number (~10,000 species) of different venomous predatory snails. The most intensively studied of these are the cone snails (Conus), which have a large number of peptide neurotoxins present in their venoms. Some cone snail venoms are lethal to man; one species causes a 70% fatality rate. How these venoms have been used to understand the nervous system, and how the characterization...

Conus Peptides: Part 2: How a Fish Hunting Snail Captures its Prey (21:31)

submitted by: scivee-team
Although snails are not the first animals that come to mind when venoms are mentioned, there are in fact a large number (~10,000 species) of different venomous predatory snails. The most intensively studied of these are the cone snails (Conus), which have a large number of peptide neurotoxins present in their venoms. Some cone snail venoms are lethal to man; one species causes a 70% fatality rate. How these venoms have been used to understand the nervous system, and how the characterization...